Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Historical trends in the epidemiology of candidaemia: analysis of an 11-year period in a tertiary care hospital in Brazil

Autor Wille, Marcos Paulo Autor UNIFESP Google Scholar
Guimarães, Thaís Autor UNIFESP Google Scholar
Furtado, Guilherme Henrique Campos Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Instituição Laboratorio Especializado em Micologia
Universidade Federal de São Paulo (UNIFESP)
Resumo Candida species are an important cause of bloodstream infections (BSI). To evaluate the epidemiological, clinical and microbiological aspects of two cohorts {1994-1999 [period 1 (P1) ]; 2000-2004 [period 2 (P2) ]} of candidaemic patients, we performed a retrospective analysis from a laboratory-based survey. A total of 388 candidaemias were identified, with an incidence of 0.20/1,000 patient-days and a significant increase in P2 vs. P1 (0.25 vs. 0.15, p = 0.04). Cancer and prior antibiotic use were frequent and Candida albicans was the most prevalent species found (42.4%). Resistance to fluconazole was found in 2.47% of the strains. No differences were observed in the species distribution of Candida during the study periods. In the P2 cohort, there were higher prevalence of elderly individuals, cardiac, pulmonary and liver diseases, renal failure, central venous catheters and antibiotic therapy. In P1, there were higher prevalence of neurological diseases and chemotherapy. The crude mortality was 55.4%. In conclusion, our incidence rates remained high. Furthermore, the distribution pattern of Candida species and the fluconazole resistance profile remained unchanged. Moreover, we found a clear trend of higher prevalence of candidaemia among the elderly and among patients with comorbidities. Finally, it is necessary to discuss strategies for the prevention and control of Candida BSI in Brazil.
Palavra-chave candidaemia
epidemiology
bloodstream infections
Idioma Inglês
Data de publicação 2013-05-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 108, n. 3, p. 288-292, 2013.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 288-292
Fonte http://dx.doi.org/10.1590/S0074-02762013000300005
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000320501000005
SciELO S0074-02762013000300288 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7741

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