Cognition and biomarkers of oxidative stress in obstructive sleep apnea

Cognition and biomarkers of oxidative stress in obstructive sleep apnea

Autor Sales, Leticia Viana Google Scholar
Bruin, Veralice Meireles Sales de Autor UNIFESP Google Scholar
D'Almeida, Vânia Autor UNIFESP Google Scholar
Pompéia, Sabine Autor UNIFESP Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Bittencourt, Lia Rita Azeredo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Ceará (UFC) Faculdade de Medicina
Resumo OBJECTIVES: The aim of this study was to investigate neuropsychological performance and biomarkers of oxidative stress in patients with obstructive sleep apnea and the relationships between these factors. METHODS: This was an observational, cross-sectional study of 14 patients (36.0±6.5 years old) with obstructive sleep apnea and 13 controls (37.3±6.9 years old). All of the participants were clinically evaluated and underwent full-night polysomnography as well as neuropsychological tests. Blood samples were used to assay superoxide dismutase, catalase, glutathione and homocysteine, as well as vitamins E, C, B11 and B12. RESULTS: The patients performed poorly relative to the controls on several neuropsychological tests, such as the attention test and tests of long-term memory and working memory/executive function. They also had lower levels of vitamin E (p<0.006), superoxide dismutase (p<0.001) and vitamin B11 (p<0.001), as well as higher concentrations of homocysteine (p<0.02). Serum concentrations of vitamin C, catalase, glutathione and vitamin B12 were unaltered. Vitamin E levels were related to performance in the backward digit span task (F = 15.9; p = 0.002) and this correlation remained after controlling for age and body mass index (F = 6.3, p = 0.01). A relationship between superoxide dismutase concentrations and executive non-perseveration errors in the Wisconsin Card Sorting Test (F = 7.9; p = 0.01) was also observed. CONCLUSIONS: Decreased levels of antioxidants and lower performance on the neuropsychological tasks were observed in patients with obstructive sleep apnea. This study suggests that an imbalance between antioxidants and pro-oxidants may contribute to neuropsychological alterations in this patient population.
Assunto Sleep Apnea
Neuropsychological Tests
Oxidative Stress
Vitamin E
Superoxide Dismutase
Idioma Inglês
Financiador AFIP
Data 2013-04-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 68, n. 4, p. 449-455, 2013.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Editor Faculdade de Medicina / USP
Extensão 449-455
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000320002000003
SciELO S1807-59322013000400449 (estatísticas na SciELO)

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