Specific insulin and proinsulin secretion in glucokinase-deficient individuals

Specific insulin and proinsulin secretion in glucokinase-deficient individuals

Autor Pardini, Victor Cavalcanti Google Scholar
Velho, Gilberto Autor UNIFESP Google Scholar
Reis, R. Google Scholar
Purisch, Saulo Google Scholar
Blanché, H. Google Scholar
Vieira, J.g.h. Autor UNIFESP Google Scholar
Moises, Regina Celia Mello Santiago Autor UNIFESP Google Scholar
Instituição Hospital Santa Casa
Hôpital Saint-Louis
Fondation Jean Dausset
Universidade Federal de São Paulo (UNIFESP)
Resumo Glucokinase (GCK) is an enzyme that regulates insulin secretion, keeping glucose levels within a narrow range. Mutations in the glucokinase gene cause a rare form of diabetes called maturity-onset diabetes of the young (MODY). An early onset (less than 25 years), autosomal dominant inheritance and low insulin secretion stimulated by glucose characterize MODY patients. Specific insulin and proinsulin were measured in serum by immunofluorimetric assays (IFMA) during a 75-g oral glucose tolerance test (OGTT). Two kindreds (SA and LZ) were studied and compared to non-diabetic unrelated individuals (control group 1) matched for age and body mass index (BMI). In one kindred, some of these subjects were also obese (BMI >26 kg/m2), and other family members also presented with obesity and/or late-onset NIDDM. The MODY patients were also compared to a group of five of their first-degree relatives with obesity and/or late-onset NIDDM. The proinsulin profile was different in members of the two MODY kindreds. Fasting proinsulin and the proinsulin/insulin ratio were similar in MODY members of kindred LZ and subjects from control group 1, but were significantly lower than in MODY members of kindred SA (P<0.02 and P<0.01, for proinsulin and proinsulin/insulin ratio, respectively). Moreover, MODY members of family SA had higher levels of proinsulin and proinsulin/insulin ratio, although not significantly different, when compared to their first-degree relatives and to subjects from control group 2. In conclusion, we observed variable degrees of proinsulin levels and proinsulin/insulin ratio in MODY members of two different kindreds. The higher values of these parameters found in MODY and non-MODY members of kindred SA is probably related to the obesity and late-onset NIDDM background present in this family.
Assunto proinsulin
Idioma Inglês
Data 1999-04-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 4, p. 427-430, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Editor Associação Brasileira de Divulgação Científica
Extensão 427-430
Fonte http://dx.doi.org/10.1590/S0100-879X1999000400008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000079864800008
SciELO S0100-879X1999000400008 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/766

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