Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

Autor Yasojima, Edson Yuzur Google Scholar
Teixeira, Renan Kleber Costa Google Scholar
Houat, Abdallah de Paula Google Scholar
Costa, Felipe Lobato da Silva Google Scholar
Silveira, Edvaldo Lima Google Scholar
Brito, Marcus Vinicius Henriques Google Scholar
Lopes Filho, Gaspar de Jesus Autor UNIFESP Google Scholar
Instituição UEPA Medical School
Universidade Federal de São Paulo (UNIFESP)
Resumo PURPOSE: To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/polyglecaprone mesh in rats. METHODS: A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS: All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION: Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.
Palavra-chave Surgical Mesh
Collagen
Wound Healing
Rats
Idioma Inglês
Data de publicação 2013-02-01
Publicado em Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 2, p. 131-135, 2013.
ISSN 0102-8650 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extensão 131-135
Fonte http://dx.doi.org/10.1590/S0102-86502013000200008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000314365100008
SciELO S0102-86502013000200008 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7631

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