Giant cell arteritis: a multicenter observational study in Brazil

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dc.contributor.author Souza, Alexandre Wagner Silva de [UNIFESP]
dc.contributor.author Okamoto, Karine Yoshiye Kajiyama [UNIFESP]
dc.contributor.author Abrantes, Fabiano [UNIFESP]
dc.contributor.author Schau, Bruno
dc.contributor.author Bacchiega, Ana Beatriz Santos
dc.contributor.author Shinjo, Samuel Katsuyuki [UNIFESP]
dc.date.accessioned 2015-06-14T13:45:14Z
dc.date.available 2015-06-14T13:45:14Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.6061/clinics/2013(03)OA06
dc.identifier.citation Clinics. Faculdade de Medicina / USP, v. 68, n. 3, p. 317-322, 2013.
dc.identifier.issn 1807-5932
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/7584
dc.description.abstract OBJECTIVE: To describe demographic features, disease manifestations and therapy in patients with giant cell arteritis from referral centers in Brazil. METHODS: A retrospective cohort study was performed on 45 giant cell arteritis patients from three university hospitals in Brazil. Diagnoses were based on the American College of Rheumatology classification criteria for giant cell arteritis or temporal artery biopsy findings. RESULTS: Most patients were Caucasian, and females were slightly more predominant. The frequencies of disease manifestations were as follows: temporal headache in 82.2%, neuro-ophthalmologic manifestations in 68.9%, jaw claudication in 48.9%, systemic symptoms in 44.4%, polymyalgia rheumatica in 35.6% and extra-cranial vessel involvement in 17.8% of cases. Aortic aneurysms were observed in 6.6% of patients. A comparison between patients with biopsy-proven giant cell arteritis and those without temporal artery biopsies did not yield significant differences in disease manifestations. All patients were treated with oral prednisone, and intravenous methylprednisolone was administered to nearly half of the patients. Methotrexate was the most commonly used immunosuppressive agent, and low-dose aspirin was prescribed to the majority of patients. Relapses occurred in 28.9% of patients, and aspirin had a protective effect against relapses. Females had higher prevalences of polymyalgia rheumatica, systemic manifestations and jaw claudication, while permanent visual loss was more prevalent in men. CONCLUSIONS: Most of the clinical features of Brazilian giant cell arteritis patients were similar to those found in other studies, except for the high prevalence of neuro-ophthalmic manifestations and permanent blindness in the Brazilian patients. Aspirin had a protective effect on relapses. en
dc.format.extent 317-322
dc.language.iso eng
dc.publisher Faculdade de Medicina / USP
dc.relation.ispartof Clinics
dc.rights Acesso aberto
dc.subject Giant Cell Arteritis en
dc.subject Glucocorticoids en
dc.subject Methotrexate en
dc.subject Multicenter Study en
dc.subject Vasculitis en
dc.title Giant cell arteritis: a multicenter observational study in Brazil en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade do Estado do Rio de Janeiro Rheumatology Division
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Rheumatology Division
dc.description.affiliation Universidade do Estado do Rio de Janeiro Rheumatology Division
dc.description.affiliation Universidade de São Paulo Faculdade de Medicina Hospital das Clínicas
dc.description.affiliationUnifesp UNIFESP, Rheumatology Division
dc.identifier.file S1807-59322013000300007.pdf
dc.identifier.scielo S1807-59322013000300007
dc.identifier.doi 10.6061/clinics/2013(03)OA06
dc.description.source SciELO
dc.identifier.wos WOS:000320000800007



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