Giant cell arteritis: a multicenter observational study in Brazil

Giant cell arteritis: a multicenter observational study in Brazil

Author Souza, Alexandre Wagner Silva de Autor UNIFESP Google Scholar
Okamoto, Karine Yoshiye Kajiyama Autor UNIFESP Google Scholar
Abrantes, Fabiano Autor UNIFESP Google Scholar
Schau, Bruno Google Scholar
Bacchiega, Ana Beatriz Santos Google Scholar
Shinjo, Samuel Katsuyuki Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Universidade do Estado do Rio de Janeiro Rheumatology Division
Universidade de São Paulo (USP)
Abstract OBJECTIVE: To describe demographic features, disease manifestations and therapy in patients with giant cell arteritis from referral centers in Brazil. METHODS: A retrospective cohort study was performed on 45 giant cell arteritis patients from three university hospitals in Brazil. Diagnoses were based on the American College of Rheumatology classification criteria for giant cell arteritis or temporal artery biopsy findings. RESULTS: Most patients were Caucasian, and females were slightly more predominant. The frequencies of disease manifestations were as follows: temporal headache in 82.2%, neuro-ophthalmologic manifestations in 68.9%, jaw claudication in 48.9%, systemic symptoms in 44.4%, polymyalgia rheumatica in 35.6% and extra-cranial vessel involvement in 17.8% of cases. Aortic aneurysms were observed in 6.6% of patients. A comparison between patients with biopsy-proven giant cell arteritis and those without temporal artery biopsies did not yield significant differences in disease manifestations. All patients were treated with oral prednisone, and intravenous methylprednisolone was administered to nearly half of the patients. Methotrexate was the most commonly used immunosuppressive agent, and low-dose aspirin was prescribed to the majority of patients. Relapses occurred in 28.9% of patients, and aspirin had a protective effect against relapses. Females had higher prevalences of polymyalgia rheumatica, systemic manifestations and jaw claudication, while permanent visual loss was more prevalent in men. CONCLUSIONS: Most of the clinical features of Brazilian giant cell arteritis patients were similar to those found in other studies, except for the high prevalence of neuro-ophthalmic manifestations and permanent blindness in the Brazilian patients. Aspirin had a protective effect on relapses.
Keywords Giant Cell Arteritis
Glucocorticoids
Methotrexate
Multicenter Study
Vasculitis
Language English
Date 2013-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 68, n. 3, p. 317-322, 2013.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 317-322
Origin http://dx.doi.org/10.6061/clinics/2013(03)OA06
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000320000800007
SciELO ID S1807-59322013000300007 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7584

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