Effects of preoperative irradiation using fractioned electron beam on the healing process of colocolonic anastomosis in rats undergoing early and late surgical intervention

Effects of preoperative irradiation using fractioned electron beam on the healing process of colocolonic anastomosis in rats undergoing early and late surgical intervention

Autor Simões Neto, Joaquim Autor UNIFESP Google Scholar
Reis Neto, José Alfredo Dos Google Scholar
Matos, Delcio Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
PUCCAMP Department of Surgery
Metropolitan University of Santos
Resumo PURPOSE: To investigate the effects of preoperative fractioned irradiation using an electron beam on the healing process of colocolonic anastomoses in rats that underwent early and late surgical intervention. METHODS: Thirty Wistar rats, distributed as follows: group A (surgery only), group B (fractionated irradiation for 30 days (if), surgery seven days after the end of it), group C (if for 30 days, and surgery after 30 days of termination). On the seventh postoperative day the anastomotic segment analysis was taken, using tension tests, histology and collagen deposition evaluation by computerized analysis. RESULTS: Regarding the tension resistance of the anastomosis, there were no statistical differences (p=0.42). However, a significant increase in cells number in the inflammatory infiltrate in the group with a longer interval between surgery and pre op radiation (p<0.05). The collagen concentration had no significant variance. CONCLUSION: The irradiation in divided doses increased local inflammatory cellularity when the surgery was performed later. This result did not affect the increase of complications, nor on the local concentration of collagen, achieving similar clinical outcomes.
Palavra-chave Dose Fractionation
Anastomosis, Surgical
Colon
Wound Healing
Surgical Procedures, Operative
Rats
Idioma Inglês
Data de publicação 2013-01-01
Publicado em Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 72-77, 2013.
ISSN 0102-8650 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extensão 72-77
Fonte http://dx.doi.org/10.1590/S0102-86502013000100012
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000313866600011
SciELO S0102-86502013000100012 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7582

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