Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

Show simple item record

dc.contributor.author Heinke, Thais [UNIFESP]
dc.contributor.author Espiríto Santo, Kleber Simões do
dc.contributor.author Longatto Filho, Adhemar
dc.contributor.author Stávale, João Norberto [UNIFESP]
dc.date.accessioned 2015-06-14T13:45:11Z
dc.date.available 2015-06-14T13:45:11Z
dc.date.issued 2013-01-01
dc.identifier http://dx.doi.org/10.1590/S0102-86502013000100008
dc.identifier.citation Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 48-54, 2013.
dc.identifier.issn 0102-8650
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/7540
dc.description.abstract PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention. en
dc.format.extent 48-54
dc.language.iso eng
dc.publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
dc.relation.ispartof Acta Cirurgica Brasileira
dc.rights Acesso aberto
dc.subject Glioma en
dc.subject Neovascularization, Pathologic en
dc.subject Immunohistochemistry en
dc.title Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Clinical Hospital Luzia de Pinho Melo
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation UNIFESP-EPM Investigative Pathology Division
dc.description.affiliation Clinical Hospital Luzia de Pinho Melo
dc.description.affiliation University of São Paulo Faculty of Medicine Laboratory of Medical Investigation
dc.description.affiliationUnifesp UNIFESP, EPM, Investigative Pathology Division
dc.identifier.file S0102-86502013000100008.pdf
dc.identifier.scielo S0102-86502013000100008
dc.identifier.doi 10.1590/S0102-86502013000100008
dc.description.source SciELO
dc.identifier.wos WOS:000313866600007



File

Name: S0102-86502013000100008.pdf
Size: 1.195Mb
Format: PDF
Description:
Open file

This item appears in the following Collection(s)

Show simple item record

Search


Browse

Statistics

My Account