Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

Vascular endothelial growth factor and KIT expression in relation with microvascular density and tumor grade in supratentorial astrocytic tumors

Author Heinke, Thais Autor UNIFESP Google Scholar
Espiríto Santo, Kleber Simões do Google Scholar
Longatto Filho, Adhemar Google Scholar
Stávale, João Norberto Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Clinical Hospital Luzia de Pinho Melo
Universidade de São Paulo (USP)
Abstract PURPOSE: To evaluate the relationship between microvascular density and the expression of vascular endothelial growth factor (VEGF) and KIT as possible markers of angiogenic stimulus in astrocytic tumors and correlate it with histopathological grading. METHODS: We enrolled 99 surgical specimens of supratentorial astrocytic tumors for analysis of VEGF and KIT and subsequent correlation with MVD and grading. RESULTS: KIT and VEGF expression correlated with microvascular density (p<0.005) and both VEGF and microvascular density correlated with grading (p<0.005). KIT had no significant relationship with grading (p=0.657). CONCLUSION: KIT and VEGF constitute important pathways in the angiogenesis of astrocytomas and therefore are promising prognostic tools and options for therapeutic intervention.
Keywords Glioma
Neovascularization, Pathologic
Immunohistochemistry
Language English
Date 2013-01-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 48-54, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 48-54
Origin http://dx.doi.org/10.1590/S0102-86502013000100008
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000313866600007
SciELO ID S0102-86502013000100008 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7540

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