Reduced bone mineral density in men after heart transplantation

Reduced bone mineral density in men after heart transplantation

Autor Anijar, José Ricardo Google Scholar
Szejnfeld, Vera Lucia Autor UNIFESP Google Scholar
Almeida, Dirceu Rodrigues de Autor UNIFESP Google Scholar
Fernandes, Artur da Rocha Correa Autor UNIFESP Google Scholar
Ferraz, Marcos Bosi Autor UNIFESP Google Scholar
Instituição A01
A02
Universidade Federal de São Paulo (UNIFESP)
Resumo Heart transplantation is associated with rapid bone loss and an increased prevalence and incidence of fractures. The aim of the present study was to compare the bone mineral density (BMD) of 30 heart transplant (HT) recipients to that of 31 chronic heart failure (CHF) patients waiting for transplantation and to determine their biochemical markers of bone resorption and hormone levels. The BMD of lumbar spine and proximal femur was determined by dual-energy X-ray absorptiometry. Anteroposterior and lateral radiographs of the thoracic and lumbar spine were also obtained. The mean age of the two groups did not differ significantly. Mean time of transplantation was 25.4 ± 21.1 months (6 to 88 months). Except for the albumin levels, which were significantly higher, and magnesium levels, which were significantly lower in HT patients when compared to CHF patients, all other biochemical parameters and hormone levels were within the normal range and similar in the two groups. Both groups had lower BMD of the spine and proximal femur compared to young healthy adults. However, the mean BMD of HT patients was significantly lower than in CHF patients at all sites studied. Bone mass did not correlate with time after transplantation or cumulative dose of cyclosporine A. There was a negative correlation between BMD and the cumulative dose of prednisone. These data suggest that bone loss occurs in HT patients mainly due to the use of corticosteroids and that in 30% of the patients it can be present before transplantation. It seems that cyclosporine A may also play a role in this loss.
Palavra-chave osteoporosis
corticosteroids
heart transplantation
Idioma Inglês
Data de publicação 1999-04-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 4, p. 413-420, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 413-420
Fonte http://dx.doi.org/10.1590/S0100-879X1999000400006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000079864800006
SciELO S0100-879X1999000400006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/753

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