Unripe Musa sapientum peel in the healing of surgical wounds in rats

Unripe Musa sapientum peel in the healing of surgical wounds in rats

Author Atzingen, Dênia Amélia Novato Castelli Von Autor UNIFESP Google Scholar
Gragnani, Alfredo Autor UNIFESP Google Scholar
Veiga, Daniela Francescato Autor UNIFESP Google Scholar
Abla, Luiz Eduardo Felipe Autor UNIFESP Google Scholar
Cardoso, Lorraine Lorene Felix Google Scholar
Ricardo, Thiago Google Scholar
Mendonça, Adriana Rodrigues dos Anjos Google Scholar
Ferreira, Lydia Masako Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
UNIVAS School of Medicine
UNIVAS Department of Biology
Abstract PURPOSE: To assess the effects of unripe Musa sapientum peel on the healing of surgical wounds in rats. METHODS: One hundred and twenty Wistar rats were divided into two treatment groups of 60 animals each: the control group (gel without the active ingredient) and experimental group (4% Musa sapientum peel gel). A 4 x 4 cm surgical wound was created on the back of each animal. The wound was cleaned daily with 0.9% saline, treated with 4% gel or natrosol gel (control), and covered with gauze. Animals from both groups were sacrificed after seven, 14 and 21 days of treatment; the tissue from the wound site was removed together with a margin of normal skin for histological analysis. RESULTS: No significant differences in wound contraction rates (p=0.982) were found between time points (seven, 14 and 21 days of treatment) in both groups. However, a significantly higher wound contraction rate was observed in the control group on day 21 compared with the experimental group (p=0.029). There were no significant differences in histomorphological features between groups. The experimental group showed an increased number of polymorphonuclear cells on day 7, with a significant reduction on day 21 (p=0.026). CONCLUSION: The use of 4% unripe Musa sapientum peel gel on surgical wounds in rats resulted in an increased number of polymorphonuclear cells on day 7, reduced wound contraction, reduced vascular proliferation and increased concentration of collagen fibers on day 21.
Keywords Musa sapientum
Wound Healing
Phytotherapy
Rats
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)
Date 2013-01-01
Published in Acta Cirurgica Brasileira. Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia, v. 28, n. 1, p. 33-38, 2013.
ISSN 0102-8650 (Sherpa/Romeo, impact factor)
Publisher Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia
Extent 33-38
Origin http://dx.doi.org/10.1590/S0102-86502013000100006
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000313866600005
SciELO ID S0102-86502013000100006 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/7504

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