The buccal mucosa fenestrated graft for Bracka first stage urethroplasty: experimental study in rabbits

The buccal mucosa fenestrated graft for Bracka first stage urethroplasty: experimental study in rabbits

Autor Oliva, Petrus Google Scholar
Delcelo, Rosana Autor UNIFESP Google Scholar
Bacelar, Herick Google Scholar
Rondon, Atila Google Scholar
Barroso Jr., Ubirajara Google Scholar
Ortiz, Valdemar Autor UNIFESP Google Scholar
Macedo Jr., Antônio Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Objective To histologically evaluate, in an experimental study in rabbits, the integration process of the buccal mucosa fenestrated graft applied in the corpora cavernosa for Bracka first stage urethroplasty. Materials and Methods A urethral defect was surgically created in 16 male rabbits of the New Zealand breed through the excision of the penile urethra. The urethral defect was corrected by applying buccal mucosa fenestrated graft through two cruciform incisions in the distal portions of its longitudinal axis. The animals were sacrificed at 2, 4, 8 and 12 weeks post surgery and their genitals were subjected to clinical and histological assessment. Results The buccal mucosa fenestrated graft showed complete uptake in all groups, with keratinization squamous metaplasia and mucosal proliferation of the fenestrated areas. The fenestrated graft area represented an increase in length of 25% in length in relation to the original standard graft. Conclusions The fenestrated buccal mucosa graft presented total integration to the adjacent epithelia with re-epithelization of the incision areas of the graft (fenestrations) and no significant inflammatory or scarring reactions when compared to other mucosa transplanted areas; therefore its application is viable in cases of extensive urethral defect whenever the donating area might be insufficient.
Palavra-chave Hypospadias
Surgery
Mouth Mucosa, Transplantation
Urethra
Models, Animal
Idioma Inglês
Data de publicação 2012-12-01
Publicado em International braz j urol. Sociedade Brasileira de Urologia, v. 38, n. 6, p. 825-832, 2012.
ISSN 1677-5538 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira de Urologia
Extensão 825-832
Fonte http://dx.doi.org/10.1590/1677-553820133806825
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000314451800020
SciELO S1677-55382012000600825 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7458

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