Resistance exercise improves hippocampus-dependent memory

Resistance exercise improves hippocampus-dependent memory

Autor Cassilhas, Ricardo Cardoso Autor UNIFESP Google Scholar
Lee, Kil Sun Autor UNIFESP Google Scholar
Venancio, Daniel Paulino Autor UNIFESP Google Scholar
Oliveira, Maria Gabriela Menezes de Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Mello, Marco Tulio de Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo It has been demonstrated that resistance exercise improves cognitive functions in humans. Thus, an animal model that mimics this phenomenon can be an important tool for studying the underlying neurophysiological mechanisms. Here, we tested if an animal model for resistance exercise was able to improve the performance in a hippocampus-dependent memory task. In addition, we also evaluated the level of insulin-like growth factor 1/insulin growth factor receptor (IGF-1/IGF-1R), which plays pleiotropic roles in the nervous system. Adult male Wistar rats were divided into three groups (N = 10 for each group): control, SHAM, and resistance exercise (RES). The RES group was submitted to 8 weeks of progressive resistance exercise in a vertical ladder apparatus, while the SHAM group was left in the same apparatus without exercising. Analysis of a cross-sectional area of the flexor digitorum longus muscle indicated that this training period was sufficient to cause muscle fiber hypertrophy. In a step-through passive avoidance task (PA), the RES group presented a longer latency than the other groups on the test day. We also observed an increase of 43 and 94% for systemic and hippocampal IGF-1 concentration, respectively, in the RES group compared to the others. A positive correlation was established between PA performance and systemic IGF-1 (r = 0.46, P < 0.05). Taken together, our data indicate that resistance exercise improves the hippocampus-dependent memory task with a concomitant increase of IGF-1 level in the rat model. This model can be further explored to better understand the effects of resistance exercise on brain functions.
Palavra-chave Physical exercise
Passive avoidance
Insulin-like growth factor 1
Resistance training
Hippocampus
Memory
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Associação Fundo de Incentivo à Pesquisa (AFIP)
Centro de Estudos em Psicobiologia e Exercicio (CEPE)
Centro de Estudo Multidisciplinar em Sonolencia e Acidentes (CEMSA)
Centro de Pesquisa, Inovacao e Difusao (CEPID-Sleep)
Número do financiamento FAPESP: 2008/03083-6
Data de publicação 2012-12-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 45, n. 12, p. 1215-1220, 2012.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1215-1220
Fonte http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012001200015
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000312461700015
SciELO S0100-879X2012001200015 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7412

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