Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

Chemical composition of hydroethanolic extracts from Siparuna guianensis, medicinal plant used as anxiolytics in Amazon region

Autor Negri, Giuseppina Autor UNIFESP Google Scholar
Santi, Daniel de Autor UNIFESP Google Scholar
Tabach, Ricardo Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Siparuna guianensis Aubl., Siparunaceae, is used as anxiolytic plants in folk medicine by South-American indians, caboclos and river-dwellers. This work focused the evaluation of phenolic composition of hydroethanolic extract of S. guianensis through HPLC-DAD-ESI/MS/MS. The constituents exhibited protonated, deprotonated and sodiated molecules and the MS/MS fragmentation of protonated, deprotonated and sodiated molecules provided product ions with rich structural information. Vicenin-2 (apigenin-6,8-di-C-glucoside) was the main constituent found in S. guianensis together quercetin-3,7-di-O-rhamnoside and kaempferol-3,7di-O-rhamnoside. A commercial extract of Passiflora incarnata (Phytomedicine) was used as surrogate standard and also was analyzed through HPLC-DAD-ESI/ MS/MS, showing flavones C-glycosides as constituents, among them, vicenin-2 and vitexin. The main constituent was vitexin. Flavonols triglycosides was also found in low content in S. guianensis and were tentatively characterized as quercetin-3O-rutinoside-7-O-rhamnoside, quercetin-3-O-pentosyl-pentoside-7-O-rhamnoside and kaempferol-3-O-pentosyl-pentoside-7-O-rhamnoside. Apigenin and kaempferol derivatives had been reported as anxiolytic agents. Flavonoids present in this extract were correlated with flavonoids reported as anxiolytics.
Assunto Siparuna guianensis
Passiflora incarnata
vitexin
vicenin-2
HPLC-DAD-ESI-MS/MS
anxiolytic activity
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Associacao Fundo de Incentivo a Psicofarmacologia (AFIP)
Data 2012-10-01
Publicado em Revista Brasileira de Farmacognosia. Sociedade Brasileira de Farmacognosia, v. 22, n. 5, p. 1024-1034, 2012.
ISSN 0102-695X (Sherpa/Romeo, fator de impacto)
Editor Sociedade Brasileira de Farmacognosia
Extensão 1024-1034
Fonte http://dx.doi.org/10.1590/S0102-695X2012005000034
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000308948000013
SciELO S0102-695X2012000500014 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/7351

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