Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection

Trans-sialidase delivered as a naked DNA vaccine elicits an immunological response similar to a Trypanosoma cruzi infection

Autor Costa, F. Autor UNIFESP Google Scholar
Pereira-Chioccola, Vera Lucia Autor UNIFESP Google Scholar
Ribeirão, M. Autor UNIFESP Google Scholar
Schenkman, Sergio Autor UNIFESP Google Scholar
Rodrigues, Mauricio Martins Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Instituto Dante Pazzanese de Cardiologia do Estado de São Paulo
Resumo Trypanosoma cruzi, the protozoan parasite that causes Chagas' disease, does not synthesize sialic acid, but expresses a trans-sialidase (TS) that catalyzes the transfer of sialic acid from host glycoconjugates to the parasite surface. Here, we review studies that characterize the immune response to the catalytic domain of the enzyme in humans during Chagas' disease or in mice following immunization with the TS gene. In both cases, there are antibodies that strongly inhibit the enzymatic activity and generation of interferon-g-producing T cells.
Palavra-chave DNA vaccination
Trans-sialidase
Chagas' disease
Idioma Inglês
Data de publicação 1999-02-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 2, p. -, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Fonte http://dx.doi.org/10.1590/S0100-879X1999000200013
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000078745300013
SciELO S0100-879X1999000200013 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/731

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