Caffeine intake by patients with autosomal dominant polycystic kidney disease

Caffeine intake by patients with autosomal dominant polycystic kidney disease

Autor Vendramini, Larissa Collis Autor UNIFESP Google Scholar
Nishiura, José Luiz Autor UNIFESP Google Scholar
Baxmann, Alessandra Calábria Autor UNIFESP Google Scholar
Heilberg, Ita Pfeferman Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Because caffeine may induce cyst and kidney enlargement in autosomal dominant polycystic kidney disease (ADPKD), we evaluated caffeine intake and renal volume using renal ultrasound in ADPKD patients. Caffeine intake was estimated by the average of 24-h dietary recalls obtained on 3 nonconsecutive days in 102 ADPKD patients (68 females, 34 males; 39 ± 12 years) and compared to that of 102 healthy volunteers (74 females, 28 males; 38 ± 14 years). The awareness of the need for caffeine restriction was assessed. Clinical and laboratory data were obtained from the medical records of the patients. Mean caffeine intake was significantly lower in ADPKD patients versus controls (86 vs 134 mg/day), and 63% of the ADPKD patients had been previously aware of caffeine restriction. Caffeine intake did not correlate with renal volume in ADPKD patients. There were no significant differences between the renal volumes of patients in the highest and lowest tertiles of caffeine consumption. Finally, age-adjusted multiple linear regression revealed that renal volume was associated with hypertension, chronic kidney disease stage 3 and the time since diagnosis, but not with caffeine intake. The present small cross-sectional study indicated a low level of caffeine consumption by ADPKD patients when compared to healthy volunteers, which was most likely due to prior awareness of the need for caffeine restriction. Within the range of caffeine intake observed by ADPKD patients in this study (0-471 mg/day), the renal volume was not directly associated with caffeine intake.
Palavra-chave Polycystic kidneys
ADPKD
Cyclic AMP
Caffeine
Nutrition
Renal volume
Idioma Inglês
Financiador Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Data de publicação 2012-09-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 45, n. 9, p. 834-840, 2012.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 834-840
Fonte http://dx.doi.org/10.1590/S0100-879X2012007500120
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000307714400007
SciELO S0100-879X2012000900007 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/7309

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