Effect of thyroparathyroidectomy on urinary acidification in diabetic rats

Effect of thyroparathyroidectomy on urinary acidification in diabetic rats

Autor Gil, Frida Zaladek Autor UNIFESP Google Scholar
Cavanal, Maria de Fátima Autor UNIFESP Google Scholar
Nascimento-Gomes, G. Autor UNIFESP Google Scholar
Silva-Rocha, M.c. Autor UNIFESP Google Scholar
Nutti-de-Almeida, M. Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In previous studies we have shown stimulation of renal acid excretion in the proximal tubules of rats with diabetes of short duration, with no important alterations in glomerular hemodynamics; on the other hand, in thyroparathyroidectomized rats (TPTX model), a significant decrease in renal acid excretion, glomerular filtration rate (GFR) and renal plasma flow (RPF) was detected. Since important changes in the parathyroid hormone-vitamin D-Ca axis are observed in the diabetic state, the present study was undertaken to investigate the renal repercussions of thyroparathyroidectomy in rats previously made diabetic by streptozotocin (45 mg/kg). Four to 6 days after the induction of diabetes (DM), a group of rats were thyroparathyroidectomized (DM + TPTX). Renal functional parameters were evaluated by measuring the inulin and sodium para-aminohippurate clearance on the tenth day. The decrease in the GFR and RPF observed in TPTX was not reversed by diabetes since the same alterations were observed in DM + TPTX. Net acid (NA) excretion was unchanged in DM (6.19 ± 0.54), decreased in TPTX (3.76 ± 0.25) and returned to normal levels in DM + TPTX (5.54 ± 0.72) when compared to the control group (6.34 ± 0.14 µmol min-1 kg-1). The results suggest that PTH plays an important vasodilator role regarding glomerular hemodynamics, since in its absence the impairment in GFR and RPF was not reversed by the diabetic state. However, with respect to acid excretion, the presence of diabetes was able to overcome the negative stimulus represented by TPTX.
Assunto diabetes
renal function
acid excretion
Idioma Inglês
Data 1999-01-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 1, p. 107-113, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Editor Associação Brasileira de Divulgação Científica
Extensão 107-113
Fonte http://dx.doi.org/10.1590/S0100-879X1999000100016
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000078324100016
SciELO S0100-879X1999000100016 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/728

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