Specific insulin and proinsulin in normal glucose tolerant first-degree relatives of NIDDM patients

Specific insulin and proinsulin in normal glucose tolerant first-degree relatives of NIDDM patients

Autor Coifman, R. Autor UNIFESP Google Scholar
Dalbosco, Ivaldir Sabino Autor UNIFESP Google Scholar
Russo, E.m.k. Autor UNIFESP Google Scholar
Moises, Regina Celia Mello Santiago Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo In order to identify early abnormalities in non-insulin-dependent diabetes mellitus (NIDDM) we determined insulin (using an assay that does not cross-react with proinsulin) and proinsulin concentrations. The proinsulin/insulin ratio was used as an indicator of abnormal ß-cell function. The ratio of the first 30-min increase in insulin to glucose concentrations following the oral glucose tolerance test (OGTT; I30-0/G30-0) was taken as an indicator of insulin secretion. Insulin resistance (R) was evaluated by the homeostasis model assessment (HOMA) method. True insulin and proinsulin were measured during a 75-g OGTT in 35 individuals: 20 with normal glucose tolerance (NGT) and without diabetes among their first-degree relatives (FDR) served as controls, and 15 with NGT who were FDR of patients with NIDDM. The FDR group presented higher insulin (414 pmol/l vs 195 pmol/l; P = 0.04) and proinsulin levels (19.6 pmol/l vs 12.3 pmol/l; P = 0.03) post-glucose load than the control group. When these groups were stratified according to BMI, the obese FDR (N = 8) showed higher fasting and post-glucose insulin levels than the obese NGT (N = 9) (fasting: 64.8 pmol/l vs 7.8 pmol/l; P = 0.04, and 60 min post-glucose: 480.6 pmol/l vs 192 pmol/l; P = 0.01). Also, values for HOMA (R) were higher in the obese FDR compared to obese NGT (2.53 vs 0.30; P = 0.075). These results show that FDR of NIDDM patients have true hyperinsulinemia (which is not a consequence of cross-reactivity with proinsulin) and hyperproinsulinemia and no dysfunction of a qualitative nature in ß-cells.
Palavra-chave insulin
NIDDM
proinsulin
first-degree relatives
Idioma Inglês
Data de publicação 1999-01-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 32, n. 1, p. 67-72, 1999.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 67-72
Fonte http://dx.doi.org/10.1590/S0100-879X1999000100010
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000078324100010
SciELO S0100-879X1999000100010 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/713

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