The persistence of multifocal colonisation by a single ABC genotype of Candida albicans may predict the transition from commensalism to infection

The persistence of multifocal colonisation by a single ABC genotype of Candida albicans may predict the transition from commensalism to infection

Autor Chaves, Guilherme Maranhão Autor UNIFESP Google Scholar
Santos, Fernanda Pahim Autor UNIFESP Google Scholar
Colombo, Arnaldo Lopes Autor UNIFESP Google Scholar
Instituição Universidade Federal do Rio Grande do Norte Faculdade de Farmácia Departamento de Análises Clínicas e Toxicológicas
Universidade Federal de São Paulo (UNIFESP)
Resumo Candida albicans is a common member of the human microbiota and may cause invasive disease in susceptible populations. Several risk factors have been proposed for candidaemia acquisition. Previous Candida multifocal colonisation among hospitalised patients may be crucial for the successful establishment of candidaemia. Nevertheless, it is still not clear whether the persistence or replacement of a single clone of C. albicans in multiple anatomical sites of the organism may represent an additional risk for candidaemia acquisition. Therefore, we prospectively evaluated the dynamics of the colonising strains of C. albicans for two groups of seven critically ill patients: group I included patients colonised by C. albicans in multiple sites who did not develop candidaemia and group II included patients who were colonised and who developed candidaemia. ABC and microsatellite genotyping of 51 strains of C. albicans revealed that patients who did not develop candidaemia were multiply colonised by at least two ABC genotypes of C. albicans, whereas candidaemic patients had highly related microsatellites and the same ABC genotype in colonising and bloodstream isolates that were probably present in different body sites before the onset of candidaemia.
Palavra-chave Candida albicans
genotyping
colonisation
bloodstream infection
strain maintenance or replacement
Idioma Inglês
Data de publicação 2012-03-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 2, p. 198-204, 2012.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 198-204
Fonte http://dx.doi.org/10.1590/S0074-02762012000200008
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000301463500008
SciELO S0074-02762012000200008 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6982

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