Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Recognition of enteroinvasive Escherichia coli and Shigella flexneri by dendritic cells: distinct dendritic cell activation states

Autor Moreno, Ana Carolina Ramos Google Scholar
Ferreira, Karen Spadari Autor UNIFESP Google Scholar
Ferreira, Lucas Gonçalves Google Scholar
Almeida, Sandro Rogério de Autor UNIFESP Google Scholar
Martinez, Marina Baquerizo Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The innate and adaptive immune responses of dendritic cells (DCs) to enteroinvasive Escherichia coli (EIEC) infection were compared with DC responses to Shigella flexneri infection. EIEC triggered DCs to produce interleukin (IL)-10, IL-12 and tumour necrosis factor (TNF)-α, whereas S. flexneri induced only the production of TNF-α. Unlike S. flexneri, EIEC strongly increased the expression of toll like receptor (TLR)-4 and TLR-5 in DCs and diminished the expression of co-stimulatory molecules that may cooperate to inhibit CD4+ T-lymphocyte proliferation. The inflammation elicited by EIEC seems to be related to innate immunity both because of the aforementioned results and because only EIEC were able to stimulate DC transmigration across polarised Caco-2 cell monolayers, a mechanism likely to be associated with the secretion of CC chemokine ligands (CCL)20 and TNF-α. Understanding intestinal DC biology is critical to unravelling the infection strategies of EIEC and may aid in the design of treatments for infectious diseases.
Palavra-chave enteroinvasive Escherichia coli
Shigella flexneri
dendritic cells
innate immune response
Idioma Inglês
Data de publicação 2012-02-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 107, n. 1, p. 138-141, 2012.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 138-141
Fonte http://dx.doi.org/10.1590/S0074-02762012000100020
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000300062500020
SciELO S0074-02762012000100020 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6958

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