Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation

Recommended screening and preventive practices for long-term survivors after hematopoietic cell transplantation

Alternative title Práticas recomendadas para triagem e prevenção de complicações em sobreviventes de longo prazo após transplante de células hematopoéticas
Author Majhail, Navneet Singh Google Scholar
Rizzo, James Douglas Google Scholar
Lee, Stephanie Joi Google Scholar
Aljurf, Mahmoud Google Scholar
Atsuta, Yoshiko Google Scholar
Bonfim, Carmem Google Scholar
Burns, Linda Jean Google Scholar
Chaudhri, Naeem Google Scholar
Davies, Stella Google Scholar
Okamoto, Shinichiro Google Scholar
Seber, Adriana Autor UNIFESP Google Scholar
Socie, Gerard Google Scholar
Szer, Jeff Google Scholar
Lint, Maria Teresa Van Google Scholar
Wingard, John Reid Google Scholar
Tichelli, Andre Google Scholar
Institution National Marrow Donor Program
Center for International Blood and Marrow Transplant Research
Fred Hutchinson Cancer Research Center
King Faisal Specialist Hospital and Research Center
Nagoya University Graduate School of Medicine
Universidade Federal do Paraná
University of Minnesota
Cincinnati Children's Hospital
Keio University School of Medicine
Universidade Federal de São Paulo (UNIFESP)
Hôpital Saint-Louis
Royal Melbourne Hospital
San Martino Hospital
University of Florida College of Medicine
University Hospital Basel
Abstract Advances in hematopoietic cell transplantation (HCT) technology and supportive care techniques have led to improvements in long-term survival after HCT. Emerging indications for transplantation, introduction of newer graft sources (e.g. umbilical cord blood) and transplantation of older patients using less intense conditioning regimens have also contributed to an increase in the number of HCT survivors. These survivors are at risk for developing late complications secondary to pre-, periand post-transplant exposures and risk-factors. Guidelines for screening and preventive practices for HCT survivors were published in 2006. An international group of transplant experts was convened in 2011 to review contemporary literature and update the recommendations while considering the changing practice of transplantation and international applicability of these guidelines. This review provides the updated recommendations for screening and preventive practices for pediatric and adult survivors of autologous and allogeneic HCT.

Os avanços na tecnologia do transplante de células hematopoéticas (TCH) e do tratamento de suporte levaram a melhoria na sobrevida a longo prazo após os TCH. Indicações emergentes de transplante, introdução de novas fontes de células (p.ex. sangue de cordão umbilical) e transplante de pacientes mais velhos utilizando regimes de condicionamento menos intensos também contribuíram para o aumento no número de sobreviventes após TCH. Estes sobreviventes estão sob risco de desenvolver complicações tardias devido a exposições e fatores de risco pré, peri e pós-transplante. Práticas recomendadas para a triagem e a prevenção de complicações em sobreviventes de TCH foram publicadas em 2006. Um grupo internacional de especialistas foi formado em 2011 para rever a literatura contemporânea e atualizar as recomendações, considerando as mudanças nas práticas de transplante e a aplicabilidade internacional destas recomendações. Esta revisão fornece as recomendações atualizadas para o diagnóstico precoce e práticas para prevenção de complicações aos sobreviventes de TCH autólogo e alogênico, adultos e crianças.
Keywords hematopoietic cell transplantation
allogeneic
autologous
late complications
screening
prevention
transplante de células-tronco hematopoéticas
alogênico
autólogo
complicações tardias
triagem
prevenção
Language English
Date 2012-01-01
Published in Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, v. 34, n. 2, p. 109-133, 2012.
ISSN 1516-8484 (Sherpa/Romeo)
Publisher Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Extent 109-133
Origin http://dx.doi.org/10.5581/1516-8484.20120032
Access rights Open access Open Access
Type Article
SciELO ID S1516-84842012000200012 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6870

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