Respiratory effects of kynurenic acid microinjected into the ventromedullary surface of the rat

Show simple item record Tolentino-Silva, Fatima Rosaria Paulino [UNIFESP] Russo, A.k. [UNIFESP] Cravo, Sergio Luiz [UNIFESP] Lopes, Oswaldo Ubriaco [UNIFESP] 2015-06-14T13:24:47Z 2015-06-14T13:24:47Z 1998-10-01
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 10, p. 1339-1343, 1998.
dc.identifier.issn 0100-879X
dc.description.abstract Several studies demonstrate that, within the ventral medullary surface (VMS), excitatory amino acids are necessary components of the neural circuits involved in the tonic and reflex control of respiration and circulation. In the present study we investigated the cardiorespiratory effects of unilateral microinjections of the broad spectrum glutamate antagonist kynurenic acid (2 nmol/200 nl) along the VMS of urethane-anesthetized rats. Within the VMS only one region was responsive to this drug. This area includes most of the intermediate respiratory area, partially overlapping the rostral ventrolateral medulla (IA/RVL). When microinjected into the IA/RVL, kynurenic acid produced a respiratory depression, without changes in mean arterial pressure or heart rate. The respiratory depression observed was characterized by a decrease in ventilation, tidal volume and mean inspiratory flow and an increase in respiratory frequency. Therefore, the observed respiratory depression was entirely due to a reduction in the inspiratory drive. Microinjections of vehicle (200 nl of saline) into this area produced no significant changes in breathing pattern, blood pressure or heart rate. Respiratory depression in response to the blockade of glutamatergic receptors inside the rostral VMS suggests that neurons at this site have an endogenous glutamatergic input controlling the respiratory cycle duration and the inspiratory drive transmission. en
dc.format.extent 1339-1343
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject ventral surface of the medulla en
dc.subject breathing pattern en
dc.subject cardiorespiratory control en
dc.subject kynurenic acid en
dc.subject rat en
dc.title Respiratory effects of kynurenic acid microinjected into the ventromedullary surface of the rat en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifesp UNIFESP
dc.identifier.file S0100-879X1998001000016.pdf
dc.identifier.scielo S0100-879X1998001000016
dc.identifier.doi 10.1590/S0100-879X1998001000016
dc.description.source SciELO
dc.identifier.wos WOS:000076614900016


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