Renal dysfunction in patients with sickle cell anemia or sickle cell trait

Renal dysfunction in patients with sickle cell anemia or sickle cell trait

Autor Sesso, Ricardo de Castro Cintra Autor UNIFESP Google Scholar
Almeida, M.a. Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Bordin, Jose Orlando Autor UNIFESP Google Scholar
Instituição A01
Universidade Federal de São Paulo (UNIFESP)
Resumo Patients with sickle cell anemia (Hb SS) or sickle cell trait (Hb AS) may present several types of renal dysfunction; however, comparison of the prevalence of these abnormalities between these two groups and correlation with the duration of disease in a large number of patients have not been thoroughly investigated. In a cross-sectional study using immunoenzymometric assays to measure tubular proteinuria, microalbuminuria, measurement of creatinine clearance, urinary osmolality and analysis of urine sediment, we evaluated glomerular and tubular renal function in 106 adults and children with Hb SS (N = 66) or Hb AS (N = 40) with no renal failure (glomerular filtration rate (GFR) >85 ml/min). The percentage of individuals with microalbuminuria was higher among Hb SS than among Hb AS patients (30 vs 8%, P<0.0001). The prevalence of microhematuria was similar in both groups (26 vs 30%, respectively). Increased urinary levels of retinol-binding protein or ß2-microglobulin were detected in only 3 Hb SS and 2 Hb AS patients. Urinary osmolality was reduced in patients with Hb SS or with Hb AS; however, it was particularly evident in Hb SS patients older than 15 years (median = 393 mOsm/kg, range = 366-469) compared with Hb AS patients (median = 541 mOsm/kg, range = 406-722). Thus, in addition to the frequently reported early reduction of urinary osmolality and increased GFR, nondysmorphic hematuria was found in 26 and 30% of patients with Hb SS or Hb AS, respectively. Microalbuminuria is an important marker of glomerular injury in patients with Hb SS and may also be demonstrated in some Hb AS individuals. Significant proximal tubular dysfunction is not a common feature in Hb SS and Hb AS population at this stage of the disease (i.e., GFR >85 ml/min).
Palavra-chave microalbuminuria
renal failure
renal function
sickle cell disease
Idioma Inglês
Data de publicação 1998-10-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 10, p. 1257-1262, 1998.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1257-1262
Fonte http://dx.doi.org/10.1590/S0100-879X1998001000004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000076614900004
SciELO S0100-879X1998001000004 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/682

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