Evaluation of the presence of microorganisms in solid-organ preservation solution

Evaluation of the presence of microorganisms in solid-organ preservation solution

Author Mattana, André Marcelo Colvara Autor UNIFESP Google Scholar
Marra, Alexandre Rodrigues Autor UNIFESP Google Scholar
Machado, Antônia Maria de Oliveira Autor UNIFESP Google Scholar
Lopes Filho, Gaspar de Jesus Autor UNIFESP Google Scholar
Salzedas-Netto, Alcides Augusto Autor UNIFESP Google Scholar
Gonzalez, Adriano Miziara Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Hospital Santo Antônio
Hospital Santa Catarina
Hospital Israelita Albert Einstein
Instituto Paulista de Doenças Infecciosas e Parasitárias
Universidade Estadual Paulista (UNESP)
Hospital do Câncer Kidney Transplantation Program
Hospital Sírio-Libanês
Abstract OBJECTIVE: To assess the presence of microorganism contamination in the preservation solution for transplant organs (kidney/pancreas). Method: Between August 2007 and March 2008, 136 samples of preservation solution were studied prior to graft implantation. Variables related to the donor and to the presence of microorganisms in the preservation solution of organs were evaluated, after which the contamination was evaluated in relation to the recipient culture variable. Univariate and multivariate statistical analyses were performed. RESULTS: The contamination rate of the preservation solution was 27.9%. Coagulase-negative Staphylococcus was the most frequently isolated microorganism. However, highly virulent agents, such as fungi and enterobacteria, were also isolated. In univariate analysis, the variable donor antibiotic use was significantly associated to the contamination of the preservation solution. On the other hand, multivariate analysis found statistical significance in donor antibiotic use and donor's infectious complications variables. CONCLUSIONS: In this study, 27.9% of the preservation solutions of transplant organs were contaminated. Infectious diseases and non-use of antibiotics by the donor were significantly related to the presence of microorganisms in organ preservation solutions. Contamination in organ preservation solutions was not associated with infection in the recipient.
Keywords organ transplantation
disease transmission, infectious
organ preservation solutions
microbial viability
Language English
Date 2011-12-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 6, p. 528-532, 2011.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Brazilian Society of Infectious Diseases
Extent 528-532
Origin http://dx.doi.org/10.1590/S1413-86702011000600005
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000298304300004
SciELO ID S1413-86702011000600005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6745

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