Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV

Human polyomaviruses JC and BK in the urine of Brazilian children and adolescents vertically infected by HIV

Autor Machado, Daisy Maria Autor UNIFESP Google Scholar
Fink, Maria Cristina Google Scholar
Pannuti, Cláudio Sérgio Google Scholar
Succi, Regina Célia de Menezes Autor UNIFESP Google Scholar
Machado, Alessandra Aparecida Google Scholar
Carmo, Fabiana Bononi do Autor UNIFESP Google Scholar
Gouvêa, Aida de Fátima Thomé Barbosa Autor UNIFESP Google Scholar
Urbano, Paulo Roberto Google Scholar
Beltrão, Suênia Vasconcelos Autor UNIFESP Google Scholar
Santos, Isabel Cristina Lopes dos Autor UNIFESP Google Scholar
Machado, Clarisse Martins Autor UNIFESP Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Federal de São Paulo (UNIFESP)
Resumo The aim of this study was to characterize the urinary excretion of the BK (BKV) and JC (JCV) human polyomaviruses in a cohort of human immunodeficiency virus (HIV)-infected children and adolescents. One hundred and fifty-six patients were enrolled: Group I included 116 HIV-infected children and adolescents [median age = 11.4 years (y); range 1-22 y]; Group II included 40 non-HIV-infected healthy controls (median age = 11.37 y; range 7-16 y). Single urine samples from both groups were screened for the presence of JCV and BKV DNA by polymerase chain reaction at enrolment. The overall rate of JCV and BKV urinary excretion was found to be 24.4% and 40.4%, respectively (n = 156). Group I had urinary excretion of JCV and BKV in 27.6% and 54.3% of subjects, respectively. In contrast, Group II showed positive results for JCV in 17.5% of subjects and for BKV in 12.5% of subjects (p Pearson JCV = 0.20; p Pearson BKV < 0.0001). In Group I, there was no association between JCV/BKV shedding and age, gender or CD4 values. Patients with an HIV viral load < 50 copies/mL had a lower excretion of BKV (p < 0.001) and a trend of lower JCV excretion (p = 0.07). One patient in Group I (1/116, 0.9%) showed clinical and radiological features consistent with progressive multifocal leukoencephalopathy, suggesting that children with HIV/polyomavirus coinfection should be kept under surveillance.
Palavra-chave HIV-1
child
adolescent
JC virus
BK virus
urine
Idioma Inglês
Data de publicação 2011-12-01
Publicado em Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 931-935, 2011.
ISSN 0074-0276 (Sherpa/Romeo, fator de impacto)
Publicador Instituto Oswaldo Cruz, Ministério da Saúde
Extensão 931-935
Fonte http://dx.doi.org/10.1590/S0074-02762011000800006
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000299068800006
SciELO S0074-02762011000800006 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6739

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