Background and paroxystic activities on AIDS patients' EEG: relation with urea and creatinine seric concentration

Background and paroxystic activities on AIDS patients' EEG: relation with urea and creatinine seric concentration

Alternative title Ritmo de base e atividade paroxística no EEG de pacientes com AIDS: relação com as concentrações séricas de uréia e creatinina
Author Prado, Gilmar Fernandes do Autor UNIFESP Google Scholar
Silva, Ademir Baptista Autor UNIFESP Google Scholar
Coelho, João Fernando Guimbra Simões Google Scholar
Braga, Nádia Iandoli Oliveira Google Scholar
Accetturi, Conceicao Aparecida Autor UNIFESP Google Scholar
Lima, José Geraldo de Camargo Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Instituto de Infectologia Emílio Ribas
Abstract The HIV is responsible for important metabolic and structural alterations of the brain. This affected brain must react to continuous systemic metabolic fluctuations. We search for possibly resulting cerebral electric disturbance that could be found by EEG exploration. Sixty-three AIDS patients ranked as CDC group IV had their EEG background rhythm measured, and were appointed to mutually exclusiding groups delimited by medians' values of urea (24 mg/dl) and creatinine (0.9 mg/dl) seric concentrations. These groups were independently formed for each of the parameters utilized, and each data pair generated therefrom were compared between themselves to verify whether there were differences in background rhythm and the occurrence of paroxysmal activity. Background rhythm and paroxysmal activities have not statistically differed between the group whose creatinine values were lower than 0.9 mg/dl and the group whose creatinine values were equal or higher than 0.9 mg/dl. Background rhythm has not statistically differed between the group whose ures values were <24 mg/dl and the group whose urea values were =24 mg/dl; contrariwise, the occurrence of paroxysmal activities in these groups has significatively differed, being higher in the patient group whose otherwise normal urea values exceeded 24 mg/dl (p=0.02).

Sendo o HIV responsável por alterações estruturais e metabólicas do encéfalo, procuramos verificar se pequenas alterações metabólicas sistêmicas poderiam determinar alterações encefálicas detectáveis através do EEG. Medimos o ritmo de base no EEG de 63 pacientes aidéticos no grupo IV da classificação do CDC e, utilizando os valores das medianas das taxas de uréia e creatinina séricas, constituímos dois grupos para cada um dos referidos parâmetros. Verificamos se os EEGs dos pacientes com uréia abaixo do valor mediano (24 mg/dl), diferiam em relação ao ritmo de base e presença de atividade paroxística, daqueles com uréia = 24 mg/dl. Procedemos da mesma forma para estudar o ritmo de base e atividade paroxística em relação à mediana das concentrações de creatinina (0,9 mg/dl). O ritmo de base e a ocorrência de atividade paroxística não foram diferentes em relação à concentração de creatinina. O mesmo ocorreu em relação ao ritmo de base e concentração de uréia. Observamos, entretanto, maior número de EEGs de pacientes com uréia normal acima de 24 mg/dl com atividade paroxística (p=0,02).
Keywords paroxystic activity
background activity
EEG
HIV
urea
creatinine
AIDS
atividade paroxística
atividade de base
EEG
HIV
uréia
creatinina
AIDS
SIDA
Language English
Date 1998-09-01
Published in Arquivos de Neuro-Psiquiatria. Academia Brasileira de Neurologia - ABNEURO, v. 56, n. 3A, p. 350-355, 1998.
ISSN 0004-282X (Sherpa/Romeo, impact factor)
Publisher Academia Brasileira de Neurologia - ABNEURO
Extent 350-355
Origin http://dx.doi.org/10.1590/S0004-282X1998000300002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000075266000002
SciELO ID S0004-282X1998000300002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/672

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