Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals

Cotrimoxazole enhances the in vitro susceptibility of Coccidioides posadasii to antifungals

Author Cordeiro, Rossana de Aguiar Google Scholar
Astete-Medrano, Delia Jessica Google Scholar
Marques, Francisca Jakelyne de Farias Google Scholar
Andrade, Heuziwanne Tavares Leite Google Scholar
Perdigão Neto, Lauro Vieira Google Scholar
Tavares, Juliane Lira Google Scholar
Lima, Rita Amanda Chaves de Google Scholar
Patoilo, Kharla Kharolyni Nobre Rabelo Google Scholar
Monteiro, Andre Jalles Google Scholar
Brilhante, Raimunda Sâmia Nogueira Google Scholar
Rocha, Marcos Fábio Gadelha Google Scholar
Camargo, Zoilo Pires de Autor UNIFESP Google Scholar
Sidrim, José Júlio Costa Google Scholar
Institution Universidade Federal do Ceará Centro Especializado em Micologia Médica
Universidade Federal do Ceará Programa de Pós-Graduação em Ciências Médicas
Universidade Federal do Ceará Departamento de Química
Universidade Federal do Ceará Departamento de Estatística
Universidade Estadual do Ceará Programa de Pós-Graduação em Ciência Veterinária
Universidade Federal de São Paulo (UNIFESP)
Abstract The aim of the present study was to evaluate the effect of cotrimoxazole on the in vitro susceptibility of Coccidioides posadasii strains to antifungals. A total of 18 strains of C. posadasii isolated in Brazil were evaluated in this study. The assays were performed in accordance with the Clinical and Laboratory Standards Institute guidelines and the combinations were tested using the checkerboard method. The minimum inhibitory concentrations were reduced by 11, 2.4, 4.3 and 3.5 times for amphotericin B, itraconazole, fluconazole and voriconazole, respectively. Moreover, it was seen that cotrimoxazole itself inhibited C. posadasii strains in vitro. The impairment of folic acid synthesis may be a potential antifungal target for C. posadasii.
Keywords Coccidioides posadasii
cotrimoxazole
antifungals
susceptibility
antimicrobial synergism
Language English
Date 2011-12-01
Published in Memórias do Instituto Oswaldo Cruz. Instituto Oswaldo Cruz, Ministério da Saúde, v. 106, n. 8, p. 1045-1048, 2011.
ISSN 0074-0276 (Sherpa/Romeo, impact factor)
Publisher Instituto Oswaldo Cruz, Ministério da Saúde
Extent 1045-1048
Origin http://dx.doi.org/10.1590/S0074-02762011000800024
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000299068800024
SciELO ID S0074-02762011000800024 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6714

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