Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers

Multicomponent complex formation between pyrimethamine, cyclodextrins and water-soluble polymers

Autor Rodrigues, Leticia Norma Carpentieri Autor UNIFESP Google Scholar
Issa, Michelle Georges Google Scholar
Asbahr, Ana Carolina Cavassin Google Scholar
Silva, Marco Aurélio Carvalho Google Scholar
Ferraz, Humberto Gomes Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná
Universidade Positivo
Universidade de São Paulo (USP)
Resumo The combined effect of hydroxypropyl-β-cyclodextrin (HPβCD) and polyvinylpyrrolidone (PVP) or sodium carboxymethylcellulose (CMC) on the solubility of pyrimethamine (PYR) was studied. Equimolar PYR-HPβCD solid systems, in the presence or the absence of 0.25% (w/v) PVP or 0.10% (w/v) CMC were prepared by coevaporation or freeze-drying, and characterized by differential scanning calorimetry, X-ray diffraction analysis and dissolution profile. Phase-solubility analysis was used to investigate the interactions in aqueous solution between PYR and HPβCD, in the absence or presence of polymers, which showed a linear increase of PYR solubility depending on the concentration of HPβCD. The presence of polymer did not alter the stoichiometry of the complexes. DSC results were indicative of complexation, due to the loss of the characteristic endothermic peak of PYR. X-ray diffraction analysis confirmed the DSC results. Binary and ternary complexes showed higher dissolution rate when compared with the pure drug.
Palavra-chave Pyrimethamine
HPβCD
inclusion complexes
Idioma Inglês
Data de publicação 2011-10-01
Publicado em Brazilian Archives of Biology and Technology. Instituto de Tecnologia do Paraná - Tecpar, v. 54, n. 5, p. 965-972, 2011.
ISSN 1516-8913 (Sherpa/Romeo, fator de impacto)
Publicador Instituto de Tecnologia do Paraná - Tecpar
Extensão 965-972
Fonte http://dx.doi.org/10.1590/S1516-89132011000500014
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000297761500014
SciELO S1516-89132011000500014 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6659

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