Age-related testosterone decline in a Brazilian cohort of healthy military men

Age-related testosterone decline in a Brazilian cohort of healthy military men

Autor Nardozza Júnior, Archimedes Autor UNIFESP Google Scholar
Szelbracikowski, Sérgio dos Santos Autor UNIFESP Google Scholar
Nardi, Aguinaldo Cesar Autor UNIFESP Google Scholar
Almeida, José Carlos de Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Escola de Saúde do Exército
Brazilian Society of Urology
Resumo INTRODUCTION: Androgen decline in the aging man has become a topic of increasing clinical relevance worldwide, as the reduction in testosterone levels has been reported to be accompanied by loss of muscle mass, accumulation of central adiposity, impaired mobility and increase risk of bone fractures. Although well-established in studies conducted in developed countries, progressive decline in serum testosterone levels with age has been poorly investigated in Brazil. AIM: To determine the pattern of blood testosterone concentrations decline with age in a cohort of Brazilian healthy military men. MATERIALS AND METHODS: We retrospectively reviewed data on serum testosterone measurements of healthy individuals that had undergone a routine check-up at the Military Biology Institute. Blood samples were obtained early in the morning, and total testosterone concentration was determined using a commercial chemoluminescent immunoassay. Mean values were analyzed in five age groups: < 40, 41 to 50, 51 to 60, 61 to 70, and > 70 years. MAIN OUTCOME MEASURE: Mean total testosterone levels. RESULTS: 1,623 subjects were included in the analysis; mean age was 57 years (24 to 87), and mean testosterone level was 575.5 ng/dL (25.0 to 1308.0 ng/dL). The evaluation of age-related changes in total testosterone levels revealed a progressive reduction in serum levels of this hormone with increasing age. Testosterone levels below 300 ng/dL were reported in 321 participants, a prevalence of nearly 20% in the study population. CONCLUSION: In agreement with other findings, a reduction of total testosterone levels with age was reported for healthy Brazilian men.
Palavra-chave testosterone
male
deficiency
epidemiological studies
cohort studies
Idioma Inglês
Data de publicação 2011-10-01
Publicado em International braz j urol. Sociedade Brasileira de Urologia, v. 37, n. 5, p. 591-597, 2011.
ISSN 1677-5538 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira de Urologia
Extensão 591-597
Fonte http://dx.doi.org/10.1590/S1677-55382011000500004
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000299854100004
SciELO S1677-55382011000500004 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6647

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