Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

Author López, R.v.m. Google Scholar
Zago, M.a. Google Scholar
Eluf-Neto, J. Google Scholar
Curado, M.p. Google Scholar
Daudt, A.w. Google Scholar
Da Silva-Junior, W.a. Google Scholar
Zanette, D.l. Google Scholar
Levi, J.e. Google Scholar
De Carvalho, M.b. Google Scholar
Kowalski, Luiz Paulo Autor UNIFESP Google Scholar
Abrahão, Márcio Autor UNIFESP Google Scholar
De Góis-Filho, J.f. Google Scholar
Boffetta, P. Google Scholar
Wünsch-filho, V. Google Scholar
Institution Universidade de São Paulo (USP)
Registro de Câncer de Base Populacional de Goiânia Hospital Araújo Jorge
World Health Organization International Agency for Research on Cancer
Hospital de Clínicas de Porto Alegre Departamento de Oncologia
Hospital Heliópolis Departamento de Cirurgia de Cabeça e Pescoço
Hospital do Câncer A.C. Camargo Departamento de Cirurgia de Cabeça e Pescoço
Universidade Federal de São Paulo (UNIFESP)
Instituto do Câncer Arnaldo Vieira de Carvalho Departamento de Cirurgia de Cabeça e Pescoço
Mount Sinai School of Medicine The Tisch Cancer Institute
International Prevention Research Institute
Abstract The association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.
Keywords Smoking
Alcohol
Interleukin
Head and neck cancer
Cancer prognosis
Survival analysis
Language English
Date 2011-10-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1006-1012, 2011.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1006-1012
Origin http://dx.doi.org/10.1590/S0100-879X2011007500097
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000295721600005
SciELO ID S0100-879X2011001000005 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6644

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