Prenatally programmed hypertension: role of maternal diabetes

Prenatally programmed hypertension: role of maternal diabetes

Autor Gomes, Guiomar Nascimento Autor UNIFESP Google Scholar
Gil, Frida Zaladek Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of diabetes among pregnant women. In this review, we discuss how renal and extrarenal mechanisms participate in the genesis of hypertension induced by a diabetic status during fetal development.
Palavra-chave Hypertension
Maternal diabetes
Renal impairment
Sodium retention
Idioma Inglês
Data de publicação 2011-09-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 9, p. 899-904, 2011.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 899-904
Fonte http://dx.doi.org/10.1590/S0100-879X2011007500109
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000295721500011
SciELO S0100-879X2011000900011 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6592

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