Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning

Anterograde effects of a single electroconvulsive shock on inhibitory avoidance and on cued fear conditioning

Autor Oliveira, Maria Gabriela Menezes de Autor UNIFESP Google Scholar
Bueno, Orlando Francisco Amodeo Autor UNIFESP Google Scholar
Gugliano, Eric Boragan Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Resumo A single electroconvulsive shock (ECS) or a sham ECS was administered to male 3-4-month-old Wistar rats 1, 2, and 4 h before training in an inhibitory avoidance test and in cued classical fear conditioning (measured by means of freezing time in a new environment). ECS impaired inhibitory avoidance at all times and, at 1 or 2 h before training, reduced freezing time before and after re-presentation of the ECS. These results are interpreted as a transient conditioned stimulus (CS)-induced anxiolytic or analgesic effect lasting about 2 h after a single treatment, in addition to the known amnesic effect of the stimulus. This suggests that the effect of anterograde learning impairment is demonstrated unequivocally only when the analgesic/anxiolytic effect is over (about 4 h after ECS administration) and that this impairment of learning is selective, affecting inhibitory avoidance but not classical fear conditioning to a discrete stimulus.
Palavra-chave electroconvulsive shock
memory
cued fear conditioning
inhibitory avoidance
anxiolytic effect
analgesic effect
Idioma Inglês
Data de publicação 1998-08-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 8, p. 1091-1094, 1998.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 1091-1094
Fonte http://dx.doi.org/10.1590/S0100-879X1998000800009
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000075442400009
SciELO S0100-879X1998000800009 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/659

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