Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

Involvement of catecholaminergic medullary pathways in cardiovascular responses to acute changes in circulating volume

Autor Cravo, Sergio Luiz Autor UNIFESP Google Scholar
Lopes, Oswaldo Ubriaco Autor UNIFESP Google Scholar
Pedrino, Gustavo Rodrigues Autor UNIFESP Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Universidade Federal de Goiás Departamento de Ciências Fisiológicas
Resumo Water deprivation and hypernatremia are major challenges for water and sodium homeostasis. Cellular integrity requires maintenance of water and sodium concentration within narrow limits. This regulation is obtained through engagement of multiple mechanisms and neural pathways that regulate the volume and composition of the extracellular fluid. The purpose of this short review is to summarize the literature on central neural mechanisms underlying cardiovascular, hormonal and autonomic responses to circulating volume changes, and some of the findings obtained in the last 12 years by our laboratory. We review data on neural pathways that start with afferents in the carotid body that project to medullary relays in the nucleus tractus solitarii and caudal ventrolateral medulla, which in turn project to the median preoptic nucleus in the forebrain. We also review data suggesting that noradrenergic A1 cells in the caudal ventrolateral medulla represent an essential link in neural pathways controlling extracellular fluid volume and renal sodium excretion. Finally, recent data from our laboratory suggest that these structures may also be involved in the beneficial effects of intravenous infusion of hypertonic saline on recovery from hemorrhagic shock.
Palavra-chave Baroreceptors
A1 noradrenergic neurons
Renal vascular conductance
Blood pressure
Hypertonic saline
Idioma Inglês
Data de publicação 2011-09-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 9, p. 877-882, 2011.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 877-882
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000295721500008
SciELO S0100-879X2011000900008 (estatísticas na SciELO)
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