Fractures of the proximal femur: correlation with vitamin D receptor gene polymorphism

Fractures of the proximal femur: correlation with vitamin D receptor gene polymorphism

Autor Ramalho, Ana Claudia Autor UNIFESP Google Scholar
Lazaretti-Castro, Marise Autor UNIFESP Google Scholar
Hauache, Omar Magid Autor UNIFESP Google Scholar
Kasamatsu, Teresa Sayoko Autor UNIFESP Google Scholar
Brandão, C. Google Scholar
Reis, André Fernandes Autor UNIFESP Google Scholar
Takata, Edmilson Takehiro Autor UNIFESP Google Scholar
Cafalli, Francisco Autor UNIFESP Google Scholar
Tavares, F. Google Scholar
Gimeno, Suely Godoy Agostinho Autor UNIFESP Google Scholar
Vieira, J.g.h. Google Scholar
Instituição A01
Universidade Federal de São Paulo (UNIFESP)
Hospital do Servidor Público Estadual de São Paulo
Resumo Fractures are the feared consequences of osteoporosis and fractures of the proximal femur (FPF) are those that involve the highest morbidity and mortality. Thus far, evaluation of bone mineral density (BMD) is the best way to determine the risk of fracture. Genetic inheritance, in turn, is one of the major determinants of BMD. A correlation between different genotypes of the vitamin D receptor (VDR) and BMD has been recently reported. On this basis, we decided to determine the importance of the determination of VDR genotype in the presence of an osteoporotic FPF in a Brazilian population. We studied three groups: group I consisted of 73 elderly subjects older than 65 years (78.5 ± 7.2 years) hospitalized for nonpathological FPF; group II consisted of 50 individuals older than 65 years (72.9 ± 5.2 years) without FPF and group III consisted of 98 young normal Brazilian individuals aged 32.6 ± 6.6 years (mean ± SD). Analysis of VDR gene polymorphism by restriction fragment length polymorphism (RFLP) was performed by PCR amplification followed by BsmI digestion of DNA isolated from peripheral leukocytes. The genotype distribution in group I was 20.5% BB, 42.5% Bb and 37% bb and did not differ significantly from the values obtained for group II (16% BB, 36% Bb and 48% bb) or for group III (10.2% BB, 47.6% Bb and 41.8% bb). No differences in genotype distribution were observed between sexes or between the young and elderly groups. We conclude that determination of VDR polymorphism is of no practical use for the prediction of FPF. Other nongenetic factors probably start to affect bone mass, the risk to fall and consequently the occurrence of osteoporotic fractures with advancing age.
Palavra-chave osteoporosis
fracture of proximal femur (FPF)
vitamin D receptor polymorphism
Idioma Inglês
Data de publicação 1998-07-01
Publicado em Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 7, p. 921-927, 1998.
ISSN 0100-879X (Sherpa/Romeo, fator de impacto)
Publicador Associação Brasileira de Divulgação Científica
Extensão 921-927
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000074293300006
SciELO S0100-879X1998000700006 (estatísticas na SciELO)
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