Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae

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dc.contributor.author Nogueira, Keite da Silva
dc.contributor.author Daur, Alessandra Vale
dc.contributor.author Reason, Iara Taborda de Messias
dc.contributor.author Gales, Ana Cristina [UNIFESP]
dc.contributor.author Costa, Libera Maria Dalla
dc.date.accessioned 2015-06-14T13:43:02Z
dc.date.available 2015-06-14T13:43:02Z
dc.date.issued 2011-04-01
dc.identifier http://dx.doi.org/10.1590/S1413-86702011000200014
dc.identifier.citation Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 2, p. 167-169, 2011.
dc.identifier.issn 1413-8670
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/6417
dc.description.abstract The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone > 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients. en
dc.format.extent 167-169
dc.language.iso eng
dc.publisher Brazilian Society of Infectious Diseases
dc.relation.ispartof Brazilian Journal of Infectious Diseases
dc.rights Acesso aberto
dc.subject enterobacteriaceae en
dc.subject beta-lactamases en
dc.subject cephalosporin resistance en
dc.title Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae en
dc.type Artigo
dc.contributor.institution Universidade Federal do Paraná Hospital de Clínicas
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Universidade Federal do Paraná Hospital de Clínicas
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Laboratório Alerta
dc.description.affiliationUnifesp UNIFESP, Laboratório Alerta
dc.identifier.file S1413-86702011000200014.pdf
dc.identifier.scielo S1413-86702011000200014
dc.identifier.doi 10.1590/S1413-86702011000200014
dc.description.source SciELO
dc.identifier.wos WOS:000289645600014


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