Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae

Cefepime versus extended spectrum β-lactamase-producing Enterobacteriaceae

Author Nogueira, Keite da Silva Google Scholar
Daur, Alessandra Vale Google Scholar
Reason, Iara Taborda de Messias Google Scholar
Gales, Ana Cristina Autor UNIFESP Google Scholar
Costa, Libera Maria Dalla Google Scholar
Institution Universidade Federal do Paraná Hospital de Clínicas
Universidade Federal de São Paulo (UNIFESP)
Abstract The objective of this study was to evaluate the susceptibility to cefepime of a large group of ESBL- producing enterobacteria recently isolated in a Brazilian teaching hospital . The study included 280 strains of ESBL-producing enterobacteria, isolated between 2005 and 2008. The presence of the genes blaCTX-M, blaTEM and blaSHV was determined by PCR and confirmed by nucleotide sequencing. Susceptibility testing for cefepime was performed by disc-diffusion, agar dilution method and E-test®. Among the isolates, 34 (12.1%) presented a cefepime inhibition zone > 21 and MIC < 8 mg/L by agar dilution and E-strip methods. The use of cefepime for the treatment of infections caused by ESBL-producing bacteria has been controversial. Some studies of PD/PK show the probability of achieving the required PD parameters for cefepime, when the MICs were < 8 mg/L, whereas others have reported therapeutic failure with the same MIC. Additional data is essential to come to terms about the report and treatment with cefepime in ESBL-producing organisms especially when these microorganisms are isolated from sterile sites and from critically ill patients.
Keywords enterobacteriaceae
beta-lactamases
cephalosporin resistance
Language English
Date 2011-04-01
Published in Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 2, p. 167-169, 2011.
ISSN 1413-8670 (Sherpa/Romeo, impact factor)
Publisher Brazilian Society of Infectious Diseases
Extent 167-169
Origin http://dx.doi.org/10.1590/S1413-86702011000200014
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000289645600014
SciELO ID S1413-86702011000200014 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6417

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