Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians

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dc.contributor.author Franco, Luciana Ferreira [UNIFESP]
dc.contributor.author Crispim, Felipe [UNIFESP]
dc.contributor.author Pereira, Alexandre Costa
dc.contributor.author Moises, Regina Celia Mello Santiago [UNIFESP]
dc.date.accessioned 2015-06-14T13:42:57Z
dc.date.available 2015-06-14T13:42:57Z
dc.date.issued 2011-03-01
dc.identifier http://dx.doi.org/10.1590/S0100-879X2011007500010
dc.identifier.citation Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 3, p. 240-244, 2011.
dc.identifier.issn 0100-879X
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/6343
dc.description.abstract Common variants of the transcription factor 7-like 2 (TCF7L2) gene have been found to be associated with type 2 diabetes in different ethnic groups. The Japanese-Brazilian population has one of the highest prevalence rates of diabetes. Therefore, the aim of the present study was to assess whether two single-nucleotide polymorphisms (SNPs) of TCF7L2, rs7903146 and rs12255372, could predict the development of glucose intolerance in Japanese-Brazilians. In a population-based 7-year prospective study, we genotyped 222 individuals (72 males and 150 females, aged 56.2 ± 10.5 years) with normal glucose tolerance at baseline. In the study population, we found that the minor allele frequency was 0.05 for SNP rs7903146 and 0.03 for SNP rs12255372. No significant allele or genotype association with glucose intolerance incidence was found for either SNP. Haplotypes were constructed with these two SNPs and three haplotypes were defined: CG (frequency: 0.94), TT (frequency = 0.027) and TG (frequency = 0.026). None of the haplotypes provided evidence for association with the incidence of glucose intolerance. Despite no associations between incidence of glucose intolerance and SNPs of the TCF7L2 gene in Japanese-Brazilians, we found that carriers of the CT genotype for rs7903146 had significantly lower insulin levels 2 h after a 75-g glucose load than carriers of the CC genotype. In conclusion, in Japanese-Brazilians, a population with a high prevalence of type 2 diabetes, common TCF7L2 variants did not make major contributions to the incidence of glucose tolerance abnormalities. en
dc.format.extent 240-244
dc.language.iso eng
dc.publisher Associação Brasileira de Divulgação Científica
dc.relation.ispartof Brazilian Journal of Medical and Biological Research
dc.rights Acesso aberto
dc.subject TCF7L2 en
dc.subject Glucose intolerance en
dc.subject Japanese-Brazilians en
dc.title Variants of transcription factor 7-like 2 (TCF7L2) gene and incident glucose intolerance in Japanese-Brazilians en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Universidade de São Paulo (USP)
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Endocrinologia
dc.description.affiliation Universidade de São Paulo Instituto do Coração
dc.description.affiliationUnifesp UNIFESP, EPM, Disciplina de Endocrinologia
dc.identifier.file S0100-879X2011000300011.pdf
dc.identifier.scielo S0100-879X2011000300011
dc.identifier.doi 10.1590/S0100-879X2011007500010
dc.description.source SciELO
dc.identifier.wos WOS:000288224500011



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