Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease

Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease

Author Lobo, Clarisse Lopes de Castro Google Scholar
Cançado, Rodolfo Delfini Google Scholar
Leite, Ana Claudia Celestino Bezerra Google Scholar
Anjos, Ana Claudia Mendonça dos Google Scholar
Pinto, Ana Cristina Silva Google Scholar
Matta, Andre Palma da Cunha Google Scholar
Silva, Célia Maria Google Scholar
Silva, Gisele Sampaio Autor UNIFESP Google Scholar
Friedrisch, João Ricardo Google Scholar
Braga, Josefina Aparecida Pellegrini Autor UNIFESP Google Scholar
Lange, Marcos Christiano Google Scholar
Figueiredo, Maria Stella Autor UNIFESP Google Scholar
Rugani, Marília Álvares Google Scholar
Veloso, Orlando Google Scholar
Moura, Patrícia Gomes Google Scholar
Cortez, Paulo Ivo Google Scholar
Adams, Robert Google Scholar
Gualandro, Sandra Fátima Menosi Google Scholar
Castilho, Shirley Lopes de Google Scholar
Thomé, Ursula Google Scholar
Zetola, Viviane Flumignan Google Scholar
Institution Instituto Estadual de Hematologia Arthur de Siqueira Cavalcanti
Faculdade de Ciências Médicas da Santa Casa de São Paulo
Fundação de Hematologia e Hemoterapia de Pernambuco
Universidade de São Paulo (USP)
Fundação Hemocentro
Fundação Centro de Hematologia e Hemoterapia de Minas Gerais
UFRGS Hospital de Clínicas de Porto Alegre Serviço de Hematologia e Transplante de Medula Óssea
Universidade Federal de São Paulo (UNIFESP)
Universidade Federal do Paraná Hospital de Clínicas Serviço de Neurologia
Ecodopler Laboratório
Universidade Federal do Rio de Janeiro Instituto de Puericultura e Pediatria Martagão Gesteira
Medical University of South Carolina
Abstract BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients.
Keywords Ultrasonography, doppler, transcranial
Anemia, sickle cell
Language English
Date 2011-02-01
Published in Revista Brasileira de Hematologia e Hemoterapia. Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular, v. 33, n. 1, p. 43-48, 2011.
ISSN 1516-8484 (Sherpa/Romeo)
Publisher Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
Extent 43-48
Access rights Open access Open Access
Type Article
SciELO ID S1516-84842011000100014 (statistics in SciELO)

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