Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

Clinical and microbiological characterization of KPC-producing Klebsiella pneumoniae infections in Brazil

Autor Beirão, Elisa Maria Google Scholar
Furtado, Juvencio Jose Duailibe Google Scholar
Girardello, Raquel Autor UNIFESP Google Scholar
Ferreira Filho, Heli Google Scholar
Gales, Ana Cristina Autor UNIFESP Google Scholar
Instituição Hospital Heliópolis
Hospital Heliópolis Department of Infectious Diseases
Universidade Federal de São Paulo (UNIFESP)
Hospital Heliópolis Microbiology Laboratory
Resumo In 2008 isolates of KPC-producing Klebsiella pneumoniae (KPC-KPN) were detected for the first time at Hospital Heliópolis, São Paulo, Brazil. The aim of this study was to characterize the clinical and microbiological outcomes of infections caused by KPC-KPN. A historical cohort of patients from whom KPC-KPN strains were isolated was performed. Isolates were identified as resistant to ertapenem by automated broth microdilution system and screened as carbapenemase producers by the modified Hodge test. The beta-lactamase resistance gene blaKPC was detected by PCR. The genetic relatedness of isolates was determined by PFGE. The study provides early clinical experience in treating KPC-KPN infections in a Brazilian tertiary center.
Assunto Klebsiella pneumonia
KPC
hospital infection
carbapenemase
Idioma Inglês
Data 2011-02-01
Publicado em Brazilian Journal of Infectious Diseases. Brazilian Society of Infectious Diseases, v. 15, n. 1, p. 69-73, 2011.
ISSN 1413-8670 (Sherpa/Romeo, fator de impacto)
Editor Brazilian Society of Infectious Diseases
Extensão 69-73
Fonte http://dx.doi.org/10.1590/S1413-86702011000100013
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000288385100013
SciELO S1413-86702011000100013 (estatísticas na SciELO)
URI http://repositorio.unifesp.br/handle/11600/6270

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