Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

Interleukin-8-251T > a, interleukin-1α-889C > t and apolipoprotein e polymorphisms in Alzheimer's disease

Autor Vendramini, Alex Augusto Google Scholar
Lábio, Roger Willian de Google Scholar
Rasmussen, Lucas Trevizani Autor UNIFESP Google Scholar
Reis, Nathali Mattiuzo dos Autor UNIFESP Google Scholar
Minett, Thaís Soares Cianciarullo Autor UNIFESP Google Scholar
Bertolucci, Paulo Henrique Ferreira Autor UNIFESP Google Scholar
Pinhel, Marcela Augusta de Souza Google Scholar
Souza, Dorotéia Rossi Silva Google Scholar
Mazzotti, Diego Robles Autor UNIFESP Google Scholar
Smith, Marilia de Arruda Cardoso Autor UNIFESP Google Scholar
Payão, Spencer Luiz Marques Autor UNIFESP Google Scholar
Instituição Universidade do Sagrado Coração
Faculdade de Medicina de Marília Hemocentro
Universidade Federal de São Paulo (UNIFESP)
Faculdade de Medicina de São José do Rio Preto
Resumo An inflammatory process has been involved in numerous neurodegenerative disorders such as Parkinson's disease, stroke and Alzheimer's disease (AD). In AD, the inflammatory response is mainly located in the vicinity of amyloid plaques. Cytokines, such as interleukin-8 (IL-8) and interleukin-1α (IL-1α), have been clearly involved in this inflammatory process. Polymorphisms of several interleukin genes have been correlated to the risk of developing AD. The present study investigated the association of AD with polymorphisms IL-8 -251T > A (rs4073) and IL-1α-889C > T (rs1800587) and the interactive effect of both, adjusted by the Apolipoprotein E genotype. 199 blood samples from patients with AD, 146 healthy elderly controls and 95 healthy young controls were obtained. DNA samples were isolated from blood cells, and the PCR-RFLP method was used for genotyping. The genotype distributions of polymorphisms IL-8, IL-1α and APOE were as expected under Hardy-Weinberg equilibrium. The allele frequencies did not differ significantly among the three groups tested. As expected, the APOE4 allele was strongly associated with AD (p < 0.001). No association of AD with either the IL-1α or the IL-8 polymorphism was observed, nor was any interactive effect between both polymorphisms. These results confirm previous studies in other populations, in which polymorphisms IL-8 -251T > A and IL-1α-889C > T were not found to be risk factors for AD.
Palavra-chave IL-8
IL-1α
Alzheimer's Disease
APOE
inflammatory response
Idioma Inglês
Financiador Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Universidade do Sagrado Coracao de Bauru (USC)
Faculdade de Medicina de Marilia (FAMEMA)
Número do financiamento FAPESP: 04/15273-3
Data de publicação 2011-01-01
Publicado em Genetics and Molecular Biology. Sociedade Brasileira de Genética, v. 34, n. 1, p. 1-5, 2011.
ISSN 1415-4757 (Sherpa/Romeo, fator de impacto)
Publicador Sociedade Brasileira de Genética
Extensão 1-5
Fonte http://dx.doi.org/10.1590/S1415-47572010005000098
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000287143400001
SciELO S1415-47572011000100001 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6257

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