Prior exercise training does not prevent acute cardiac alterations after myocardial infarction in female rats

Prior exercise training does not prevent acute cardiac alterations after myocardial infarction in female rats

Autor Veiga, Eduardo C. A. Autor UNIFESP Google Scholar
Antonio, Ednei Luiz Autor UNIFESP Google Scholar
Bocalini, Danilo S. Autor UNIFESP Google Scholar
Murad, Neif Google Scholar
Abreu, Luiz Carlos de Google Scholar
Tucci, Paulo José Ferreira Autor UNIFESP Google Scholar
Sato, Monica A. Google Scholar
Instituição Universidade Federal de São Paulo (UNIFESP)
Faculdade de Medicina do ABC Cardiology division Department of Medicine
Faculdade de Medicina do ABC Department of Physiology
Resumo OBJECTIVE: This study aimed to investigate whether previous exercise training could prevent or attenuate acute cardiac alterations after myocardial infarction. METHODS: Female rats were submitted to swim training (1 h/day; 5 days/week) or allowed to remain sedentary for 8 weeks. Afterwards, they were randomly assigned to left coronary artery occlusion or sham surgery. After this procedure, the rats remained sedentary for one week until euthanasia. Cardiac structural and functional analyses were performed using Doppler echocardiography. The rats that had a moderate or large infarct size were included in the evaluations. The data (mean + SEM) were analyzed using a two-way ANOVA model followed byTukey's post-hoc test. RESULTS: After the surgery, no significant difference between the exercise and sedentary groups was observed in the left ventricular infarct sizes (34.58 + 3.04 vs. 37.59 + 3.07). In another group of rats evaluated with Evans blue 1 h after myocardial infarction, no siginificant difference in the area at risk was observed between the exercised and sedentary rats (49.73 + 1.52 vs. 45.48 + 3.49). The changes in the left ventricular fractional areas for the exercised and sedentary myocardial infarction groups (36 + 2% and 39 + 3%, respectively) were smaller than those for the exercise sham surgery (ES, 67+1%) and sedentary sham surgery (SS, 69 + 2%) groups. The E/A was higher in the sedentary myocardial infarction (4.4 + 0.3) and exercised myocardial infarction (5.5 + 0.3) rats than in the SS (2.4 + 0.1) and ES (2.2 + 0.1) rats. CONCLUSION: Previous swim training of female rats does not attenuate systolic and diastolic function alterations after myocardial infarction induced by left coronary artery occlusion, suggesting that cardioprotection cannot be provided by exercise training in this experimental model.
Palavra-chave Physical Exercise
Myocardial Infarction
Remodeling
Ventricular Function
Echocardiography
Idioma Inglês
Data de publicação 2011-01-01
Publicado em Clinics. Faculdade de Medicina / USP, v. 66, n. 5, p. 889-893, 2011.
ISSN 1807-5932 (Sherpa/Romeo, fator de impacto)
Publicador Faculdade de Medicina / USP
Extensão 889-893
Fonte http://dx.doi.org/10.1590/S1807-59322011000500028
Direito de acesso Acesso aberto Open Access
Tipo Artigo
Web of Science WOS:000293122900028
SciELO S1807-59322011000500028 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6256

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