Animal models of intellectual disability: towards a translational approach

Animal models of intellectual disability: towards a translational approach

Author Scorza, Carla Alessandra Autor UNIFESP Google Scholar
Cavalheiro, Esper Abrão Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
APAE
Abstract Intellectual disability is a prevalent form of cognitive impairment, affecting 2-3% of the general population. It is a daunting societal problem characterized by significant limitations both in intellectual functioning and in adaptive behavior as expressed in conceptual, social and practical adaptive skills. Intellectual disability is a clinically important disorder for which the etiology and pathogenesis are still poorly understood. Moreover, although tremendous progress has been made, pharmacological intervention is still currently non-existent and therapeutic strategies remain limited. Studies in humans have a very limited capacity to explain basic mechanisms of this condition. In this sense, animal models have been invaluable in intellectual disability investigation. Certainly, a great deal of the knowledge that has improved our understanding of several pathologies has derived from appropriate animal models. Moreover, to improve human health, scientific discoveries must be translated into practical applications. Translational research specifically aims at taking basic scientific discoveries and best practices to benefit the lives of people in our communities. In this context, the challenge that basic science research needs to meet is to make use of a comparative approach to benefit the most from what each animal model can tell us. Intellectual disability results from many different genetic and environmental insults. Taken together, the present review will describe several animal models of potential intellectual disability risk factors.
Keywords Cognitive deficit
Down syndrome
Rett syndrome
Fragile X
Inborn errors metabolism
Language English
Date 2011-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 66, p. 55-63, 2011.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 55-63
Origin http://dx.doi.org/10.1590/S1807-59322011001300007
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000292923700007
SciELO ID S1807-59322011001300007 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6235

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