Restless legs syndrome in subjects with a knee prosthesis: evidence that symptoms are generated in the periphery

Restless legs syndrome in subjects with a knee prosthesis: evidence that symptoms are generated in the periphery

Author Pereira Júnior, José Carlos Google Scholar
Silva Neto, João Luiz Pereira da Google Scholar
Pradella-Hallinan, Márcia Lurdes de Cássia Autor UNIFESP Google Scholar
Institution Faculdade de Medicina de Jundiaí
Universidade Federal de São Paulo (UNIFESP)
Abstract OBJECTIVE: There are no data adressing the prevalence of restless legs syndrome in subjects who have knee prosthesis. Therefore, we conducted a cross-sectional survey of subjects who underwent knee prosthesis surgery. METHOD: A total of 107 subjects (30 male, 77 female) were interviewed over the telephone regarding restless legs syndrome symptoms. If the patients exhibited symptoms of the syndrome, we conducted face-to-face interviews. Lastly, a therapeutic test with pramipexole was proposed for each subject. RESULTS: In our cohort, 7 males (23%) and 30 females (39%) had restless legs syndrome. Of these, 6 males and 23 females were submitted to face-to-face-interview. Of the males, 5 (83%) had restless legs after the knee surgeryexclusively in the operated leg- and reported no family restless legs history. One man had a prior case of bilateral restless legs syndrome, a positive family history and claimed exacerbation of symptoms in the operated leg. Among the females, 16 (69%) had restless legs prior to surgery. A total of 10 female patients reported bilateral symptoms, with fewer symptoms in the operated leg, while 6 displayed a worse outcome in the operated leg. The 7 females (31%) without restless legs prior to surgery and without a family history experienced symptoms only in the operated leg. All subjects responded favorably to the pramipexole therapeutic test. CONCLUSION: Our results suggest that secondary unilateral restless legs syndrome may ensue from knee prosthesis surgery and that the symptoms are generated in the peripheral nervous system.
Keywords Restless Legs Syndrome
RLS pathophysiology
Knee prosthesis
Language English
Date 2011-01-01
Published in Clinics. Faculdade de Medicina / USP, v. 66, n. 11, p. 1955-1959, 2011.
ISSN 1807-5932 (Sherpa/Romeo, impact factor)
Publisher Faculdade de Medicina / USP
Extent 1955-1959
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000297498600017
SciELO ID S1807-59322011001100017 (statistics in SciELO)

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