Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods

Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods

Author Ferraz, Maria Lucia Cardoso Gomes Autor UNIFESP Google Scholar
Yoradjian, Alessandra Autor UNIFESP Google Scholar
Barbieri, Andrea Autor UNIFESP Google Scholar
Figueiredo, Virginia Maria Autor UNIFESP Google Scholar
Lopes Neto, Edmundo Autor UNIFESP Google Scholar
Cruz, Cibele Nascimento Autor UNIFESP Google Scholar
Silva, Antonio Eduardo Benedito Autor UNIFESP Google Scholar
Institution Universidade Federal de São Paulo (UNIFESP)
Abstract CONTEXT: HBV infection is endemic in Brazil and acute HBV infection is still a common disease. OBJECTIVE: To analyze incidence, risk factors and evolution of acute HBV infection. SETTING: University Hospital. PATIENTS: 357 patients with acute HBV infection, comparing two periods: 1985-1989 vs. 1990-1994. RESULTS: The overall incidence declined from 50 new cases/year in 1985-89 (30% of all cases) to 25 new cases/year in 1990-94 (8% of all cases). Transmission among male homosexuals (3.9% of cases in 85-89) declined to 1.3% in 90-94 (p>0.05). Amongst health care workers (HCW) it declined from 8.2% to 2.0% (p=0.02). Conversely, heterosexual transmission increased from 4.8% to 10.1% (p=0.06). Chronification of HBV infection following the acute episode was observed in 1.7%. Fulminant hepatic failure was seen in 3.4%. However, 27.2% of patients were lost to follow-up before normalization of the biochemical tests. CONCLUSIONS: The different patterns of risk factors observed is probably related to measures for preventing AIDS and to HCW vaccination programs. Chronification following acute episodes was not a common event.

CONTEXTO: A infecção pelo vírus B é endêmica no Brasil e a infecção aguda pelo HBV ainda é freqüente.OBJETIVO: Analisar a incidência, fatores de risco e formas evolutivas da hepatite aguda B. LOCAL: Hospital universitário. PARTICIPANTES: 357 pacientes com hepatite B aguda, comparando dois períodos distintos: 1985-1989 vs. 1990-1994. RESULTADOS: A incidência caiu de 50 casos novos/ano em 85-89 (30% de todos os casos atendidos), para 25 casos novos/ano (8% dos casos). A transmissão entre homossexuais caiu de 3,9% dos casos em 85-89 para 1,3% em 90-94 (p>0.05). Entre profissionais de saúde, caiu de 8,2% para 2,0% (p=0,02); Inversamente, a transmissão heterossexual aumentou de 4,8% para 10,0% (p=0,06). Cronificação seguindo um episódio agudo de hepatite B ocorreu em 1,7% dos casos. Hepatite fulminante ocorreu em 3,4% dos casos; entretanto, 27,2% dos pacientes abandonaram o seguimento antes da normalização da ALT. CONCLUSÕES: A mudança do padrão epidemiológico se deveu, possivelmente, às medidas de proteção adotadas contra a AIDS e à vacinação de profissionais de saúde. A ocorrência de cronificação após o episódio agudo foi pouco freqüente.
Keywords Hepatitis
Hepatitis B
Acute hepatitis B
Epidemiology
Language English
Date 1998-05-01
Published in São Paulo Medical Journal. Associação Paulista de Medicina - APM, v. 116, n. 3, p. 1695-1699, 1998.
ISSN 1516-3180 (Sherpa/Romeo)
Publisher Associação Paulista de Medicina - APM
Extent 1695-1699
Origin http://dx.doi.org/10.1590/S1516-31801998000300002
Access rights Open access Open Access
Type Article
SciELO ID S1516-31801998000300002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/618

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