Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients

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dc.contributor.author Etto, Leina Y [UNIFESP]
dc.contributor.author Morel, Vânia Maris [UNIFESP]
dc.contributor.author Silva, Vanderleia C [UNIFESP]
dc.contributor.author Hungria, Vania Tietsche de Moraes
dc.contributor.author Ciconelli, Rozana Mesquita [UNIFESP]
dc.contributor.author Almeida, Manuella S. S [UNIFESP]
dc.contributor.author Oliveira, José Salvador Rodrigues de [UNIFESP]
dc.contributor.author Barros, José Carlos
dc.contributor.author Durie, Brian G
dc.contributor.author Colleoni, Gisele Wally Braga [UNIFESP]
dc.date.accessioned 2015-06-14T13:42:45Z
dc.date.available 2015-06-14T13:42:45Z
dc.date.issued 2011-01-01
dc.identifier http://dx.doi.org/10.1590/S1807-59322011001100002
dc.identifier.citation Clinics. Faculdade de Medicina / USP, v. 66, n. 11, p. 1855-1859, 2011.
dc.identifier.issn 1807-5932
dc.identifier.uri http://repositorio.unifesp.br/handle/11600/6161
dc.description.abstract OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients. en
dc.description.sponsorship Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.format.extent 1855-1859
dc.language.iso eng
dc.publisher Faculdade de Medicina / USP
dc.relation.ispartof Clinics
dc.rights Acesso aberto
dc.subject Myeloma en
dc.subject Quality of life en
dc.subject SF-36 en
dc.subject QLQ-C30 en
dc.subject Transplantation en
dc.title Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients en
dc.type Artigo
dc.contributor.institution Universidade Federal de São Paulo (UNIFESP)
dc.contributor.institution Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
dc.contributor.institution Cedars-Sinai Outpatient Cancer Center
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP)
dc.description.affiliation Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas
dc.description.affiliation Universidade Federal de São Paulo (UNIFESP) Departamento de Medicina
dc.description.affiliation Cedars-Sinai Outpatient Cancer Center
dc.description.affiliationUnifesp UNIFESP, Depto. de Medicina
dc.identifier.file S1807-59322011001100002.pdf
dc.identifier.scielo S1807-59322011001100002
dc.identifier.doi 10.1590/S1807-59322011001100002
dc.description.source SciELO
dc.identifier.wos WOS:000297498600002



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