The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide

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dc.contributor.author Nazareth, Talita Corrêa
dc.contributor.author Zanutto, Conrado Planas
dc.contributor.author Tripathi, Lakshmi
dc.contributor.author Juma, Abdulaziz
dc.contributor.author Maass, Danielle [UNIFESP]
dc.contributor.author Souza, Antônio Augusto Ulson de
dc.contributor.author Souza, Selene Maria de Arruda Guelli Ulson de
dc.coverage.spatial Amsterdam pt_BR
dc.date.accessioned 2021-04-07T18:43:38Z
dc.date.available 2021-04-07T18:43:38Z
dc.date.issued 2020-10-07
dc.identifier https://www.sciencedirect.com/science/article/pii/S2215017X20304847 pt_BR
dc.identifier.issn 2215-017X pt_BR
dc.identifier.uri https://repositorio.unifesp.br/handle/11600/60837
dc.description.abstract Surfactin has potential as next generation antibiofilm agent to combat antimicrobial resistance against emerging pathogens. However, the widespread industrial applications of surfactin is hampered by its high production cost. In this work, surfactin was produced from Bacillus subtilis using a low-cost brewery waste as a carbon source. The strain produced 210.11 mg L-1 after 28 h. The antimicrobial activity was observed against all tested strains, achieving complete inhibition for Pseudomonas aeruginosa, at 500 mg mL-1. A growth log reduction of 3.91 was achieved for P. aeruginosa while, Staphylococcus aureus and Staphylococcus epidermidis showed between 1 and 2 log reductions. In the anti-biofilm assays against P. aeruginosa, the co-incubation, anti-adhesive and disruption showed inhibition, where the greatest inhibition was observed in the co-incubation assay (79.80%). This study provides evidence that surfactin produced from a low-cost substrate can be a promising biocide due to its antimicrobial and anti-biofilm abilities against pathogens. pt_BR
dc.description.sponsorship Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) pt_BR
dc.format.extent 1-10 pt_BR
dc.language eng pt_BR
dc.publisher Elsevier pt_BR
dc.relation.ispartof Biotechnology Reports pt_BR
dc.rights Acesso aberto pt_BR
dc.subject Surfactin pt_BR
dc.subject Biosurfactants pt_BR
dc.subject Brewery waste pt_BR
dc.subject Biofilm pt_BR
dc.subject Adhesion pt_BR
dc.title The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide pt_BR
dc.title.alternative The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide pt_BR
dc.type Artigo pt_BR
dc.description.sponsorshipID #2019/07659-4 pt_BR
dc.identifier.doi 10.1016/j.btre.2020.e00537 pt_BR
unifesp.campus Instituto de Ciência e Tecnologia (ICT) pt_BR
dc.contributor.authorLattes http://lattes.cnpq.br/3431482044015696 pt_BR
dc.citation.volume v. 28 pt_BR
dc.citation.issue n. e00537 pt_BR
unifesp.departamento Ciência e Tecnologia pt_BR
unifesp.assessoresproreitorias Não se aplica pt_BR



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