The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide

The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide

Alternative title The use of low-cost brewery waste product for the production of surfactin as a natural microbial biocide
Author Nazareth, Talita Corrêa Google Scholar
Zanutto, Conrado Planas Google Scholar
Tripathi, Lakshmi Google Scholar
Juma, Abdulaziz Google Scholar
Maass, Danielle Autor UNIFESP Google Scholar
Souza, Antônio Augusto Ulson de Google Scholar
Souza, Selene Maria de Arruda Guelli Ulson de Google Scholar
Abstract Surfactin has potential as next generation antibiofilm agent to combat antimicrobial resistance against emerging pathogens. However, the widespread industrial applications of surfactin is hampered by its high production cost. In this work, surfactin was produced from Bacillus subtilis using a low-cost brewery waste as a carbon source. The strain produced 210.11 mg L-1 after 28 h. The antimicrobial activity was observed against all tested strains, achieving complete inhibition for Pseudomonas aeruginosa, at 500 mg mL-1. A growth log reduction of 3.91 was achieved for P. aeruginosa while, Staphylococcus aureus and Staphylococcus epidermidis showed between 1 and 2 log reductions. In the anti-biofilm assays against P. aeruginosa, the co-incubation, anti-adhesive and disruption showed inhibition, where the greatest inhibition was observed in the co-incubation assay (79.80%). This study provides evidence that surfactin produced from a low-cost substrate can be a promising biocide due to its antimicrobial and anti-biofilm abilities against pathogens.
Keywords Surfactin
Biosurfactants
Brewery waste
Biofilm
Adhesion
xmlui.dri2xhtml.METS-1.0.item-coverage Amsterdam
Language English
Sponsor Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Grant number #2019/07659-4
Date 2020-10-07
ISSN 2215-017X (Sherpa/Romeo)
Publisher Elsevier
Extent 1-10
Origin https://www.sciencedirect.com/science/article/pii/S2215017X20304847
Access rights Open access Open Access
Type Article
URI https://repositorio.unifesp.br/handle/11600/60837

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