Antidepressant-like effects of an apolar extract and chow enriched with Nepeta cataria (catnip) in mice

Antidepressant-like effects of an apolar extract and chow enriched with Nepeta cataria (catnip) in mice

Autor Bernardi, Maria Martha Google Scholar
Kirsten, Thiago Berti Google Scholar
Salzgeber, Simone Angélica Google Scholar
Ricci, Esther Lopes Google Scholar
Romoff, Paulete Google Scholar
Lago, Joao Henrique Ghilardi Autor UNIFESP Google Scholar
Lourenço, Lygia Mendes Google Scholar
Instituição Universidade de São Paulo (USP)
Universidade Presbiteriana Mackenzie
Universidade Federal de São Paulo (UNIFESP)
Resumo Nepeta cataria (catnip) is a plant used in pet toys and to treat human diseases. Catnip has also been used in the treatment of some depressive disorders. In this paper, we studied the antidepressant, anxiogenic, and motor activity effects of acute and repeated feeding of chow enriched with 10% N. cataria leaves and the acute and repeated administration of apolar and polar extracts of N. cataria leaves in male mice. The results showed that repeated feeding and acute and repeated administration with the apolar extract reduced immobility in the behavioral despair test but did not alter elevated plus maze and open-field parameters. Acute feeding and the acute and repeated administration of the polar extracts of N. cataria leaves did not alter the behavior of mice. These data suggest that N. cataria has antidepressant properties. Moreover, this antidepressant activity was present in the apolar extract.
Palavra-chave open field
elevated plus maze
behavioral despair test
Idioma Inglês
Financiador Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Data de publicação 2010-12-01
Publicado em Psychology & Neuroscience. Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo, v. 3, n. 2, p. 251-258, 2010.
ISSN 1983-3288 (Sherpa/Romeo)
Publicador Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo
Extensão 251-258
Fonte http://dx.doi.org/10.3922/j.psns.2010.2.015
Direito de acesso Acesso aberto Open Access
Tipo Artigo
SciELO S1983-32882010000200015 (estatísticas na SciELO)
Endereço permanente http://repositorio.unifesp.br/handle/11600/6020

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