Malaria vaccine: roadblocks and possible solutions

Malaria vaccine: roadblocks and possible solutions

Author Soares, Irene da Silva Autor UNIFESP Google Scholar
Rodrigues, Mauricio Martins Autor UNIFESP Google Scholar
Institution Universidade Federal do Pará
Universidade Federal de São Paulo (UNIFESP)
Abstract Malaria remains the most prevalent and devastating parasitic disease worldwide. Vaccination is considered to be an approach that will complement other strategies for prevention and control of the disease in the future. In the last 10 years, intense studies aimed at the development of a malaria vaccine have provided important knowledge of the nature of the host immunological mechanisms of protection and their respective target antigens. It became well established that protective immune responses can be generated against the distinct stages of Plasmodium. However, in general, protective immune responses are directed at stage-specific antigens. The elucidation of the primary structure of these antigens made possible the generation of synthetic and recombinant proteins that are being extensively used in experimental immunizations against the infection. Today, several epitopes of limited polymorphism have been described and protective immunity can be generated by immunization with them. These epitopes are being tested as primary candidates for a subunit vaccine against malaria. Here we critically review the major roadblocks for the development of a malaria vaccine and provide some insight on how these problems are being solved
Keywords malaria
Plasmodium
vaccine
immunity
infectious disease
Language English
Date 1998-03-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 317-332, 1998.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 317-332
Origin http://dx.doi.org/10.1590/S0100-879X1998000300002
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000073337200002
SciELO ID S0100-879X1998000300002 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/601

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