Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study

Effects of isoflavone on the learning and memory of women in menopause: a double-blind placebo-controlled study

Author Santos-Galduróz, Ruth Ferreira Google Scholar
Galduróz, José Carlos Fernandes Autor UNIFESP Google Scholar
Facco, R.L. Google Scholar
Hachul, Helena Autor UNIFESP Google Scholar
Tufik, Sergio Autor UNIFESP Google Scholar
Institution Universidade Estadual Paulista (UNESP)
Universidade Federal do ABC Centro de Matemática, Computação e Cognição
Universidade Federal de São Paulo (UNIFESP)
Independent researcher in private practice Departamento de Psicobiologia
Abstract Hormone decline is common to all women during aging and, associated with other factors, leads to cognitive impairment. Its replacement enhances cognitive performance, but not all women present a clinical and family or personal history that justifies its use, mainly women with a history of cancer. The aim of this study was to determine whether a daily oral dose of 80 mg of isoflavone extract for 4 months can produce benefits in women with low hormone levels, contributing to improvement in cognitive aspects. The sample comprised 50- to 65-year-old women whose menstruation had ceased at least 1 year before and who had not undergone hormone replacement. The volunteers were allocated to two groups of 19 individuals each, i.e., isoflavone and placebo. There was a weak correlation between menopause duration and low performance in the capacity to manipulate information (central executive). We observed an increase in the capacity to integrate information in the group treated with isoflavone, but no improvement in the capacity to form new memories. We did not observe differences between groups in terms of signs and symptoms suggestive of depression according to the Geriatric Depression Scale. Our results point to a possible beneficial effect of isoflavone on some abilities of the central executive. These effects could also contribute to minimizing the impact of memory impairment. Further research based on controlled clinical trials is necessary to reach consistent conclusions.
Keywords Isoflavone
Cognitive disorders
Aging
Information integration
Memory
Menopause
Language English
Sponsor Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Associação Fundo de Incentivo à Pesquisa (AFIP)
Date 2010-11-01
Published in Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 43, n. 11, p. 1123-1126, 2010.
ISSN 0100-879X (Sherpa/Romeo, impact factor)
Publisher Associação Brasileira de Divulgação Científica
Extent 1123-1126
Origin http://dx.doi.org/10.1590/S0100-879X2010007500104
Access rights Open access Open Access
Type Article
Web of Science ID WOS:000284591800016
SciELO ID S0100-879X2010001100016 (statistics in SciELO)
URI http://repositorio.unifesp.br/handle/11600/6006

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